Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
G3N850_GASACSAM domain-containing protein. (612 aa)    
Predicted Functional Partners:
G3Q6V4_GASAC
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.760
G3P888_GASAC
Sterile alpha motif domain containing 1a.
    
   0.718
G3PG46_GASAC
Anaphase promoting complex subunit 5.
   
   0.712
G3N8P6_GASAC
Anaphase promoting complex subunit 1.
    
   0.688
G3N8X5_GASAC
M-phase phosphoprotein 8.
    
 0.684
RING1
Ring finger protein 1.
    
 0.671
G3PNU5_GASAC
Ring finger protein 2.
    
 0.671
G3NFG8_GASAC
Transcription factor.
   
 0.668
E2F3
E2F transcription factor 3.
    
 0.661
G3P4V1_GASAC
Si:ch211-160f23.5.
    
 0.661
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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