Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
G3NCW1_GASACHepatocyte nuclear factor 4, gamma. (474 aa)    
Predicted Functional Partners:
G3NW06_GASAC
Nuclear receptor subfamily 0, group B, member 2a.
   
 0.915
G3NRM5_GASAC
Catenin (cadherin-associated protein), beta 1.
    
 
 0.910
G3Q7H8_GASAC
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
    
 
 0.904
G3NRM9_GASAC
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.830
G3PBM0_GASAC
CREB binding protein b.
    
 
 0.829
G3PGQ4_GASAC
HNF1 homeobox a.
   
 0.816
G3Q6V4_GASAC
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.813
G3Q4J0_GASAC
CREB binding protein a.
    
 
 0.805
G3NU10_GASAC
Sp1 transcription factor.
    
 
 0.784
G3PAR7_GASAC
HNF1 homeobox Ba.
   
 0.757
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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