STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EIF2C4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (862 aa)    
Predicted Functional Partners:
G3Q9N5_GASAC
Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.
   
 0.955
TARBP2
RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]
    
 0.907
G3NWX4_GASAC
Si:dkey-217f16.6.
    
 0.879
G3Q6Y5_GASAC
Trinucleotide repeat containing adaptor 6C2.
   
 0.867
G3PMS9_GASAC
Trinucleotide repeat containing adaptor 6A.
   
 0.864
G3PFB6_GASAC
Trinucleotide repeat containing adaptor 6C1.
    
 0.863
G3NKF3_GASAC
Protein kinase, interferon-inducible double stranded RNA dependent activator.
    
 0.862
G3NPU8_GASAC
Uncharacterized protein.
   
 0.846
G3NPV2_GASAC
Uncharacterized protein.
    
 0.843
G3PT28_GASAC
Miff domain-containing protein.
   
 0.836
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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