Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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EIF2C4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (862 aa)    
Predicted Functional Partners:
G3Q9N5_GASAC
Dicer 1, ribonuclease type III; Belongs to the helicase family. Dicer subfamily.
   
 0.942
G3NKF3_GASAC
Protein kinase, interferon-inducible double stranded RNA dependent activator.
    
 0.934
TARBP2
RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]
    
 0.934
G3NWX4_GASAC
Si:dkey-217f16.6.
    
 0.897
G3Q6T9_GASAC
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 0.864
G3PFB6_GASAC
Trinucleotide repeat containing adaptor 6C1.
    
 0.852
G3PMS9_GASAC
Trinucleotide repeat containing adaptor 6A.
    
 0.852
G3Q6Y5_GASAC
Trinucleotide repeat containing adaptor 6C2.
    
 0.852
G3P815_GASAC
Family with sequence similarity 172 member A.
   
 
 0.792
G3N8X4_GASAC
Staufen double-stranded RNA binding protein 1.
   
 0.787
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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