Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RNF5Ring finger protein 5. (195 aa)    
Predicted Functional Partners:
G3NQ33_GASAC
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
 0.961
G3P2X0_GASAC
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.
    
 0.944
G3N9I1_GASAC
Transmembrane and ubiquitin-like domain containing 1.
    
 
 0.918
G3PXT7_GASAC
Ring finger protein 185.
  
  
 
0.902
G3NUA6_GASAC
ER lipid raft associated 1.
   
 0.894
G3PIX9_GASAC
Cholesterol 25-hydroxylase like 3.
   
 0.894
G3PI80_GASAC
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 
 0.888
G3Q464_GASAC
Transmembrane protein 173.
    
 
 0.856
G3PJA6_GASAC
Transmembrane protein 259.
    
 
 0.842
G3QA52_GASAC
Ubiquitin B.
   
 0.822
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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