Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (412 aa)    
Predicted Functional Partners:
G3N6M2_GASAC
Si:ch211-125a15.1.
    
 0.978
G3Q9B9_GASAC
Integrin alpha FG-GAP repeat containing 2.
    
 0.977
G3PP41_GASAC
DEP domain containing 5.
    
 0.976
G3Q9T5_GASAC
Kaptin (actin binding protein).
    
 0.958
G3N8N0_GASAC
NPR2 like, GATOR1 complex subunit.
    
 0.947
G3PHM0_GASAC
Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.
   
 0.942
G3PLC5_GASAC
NPR3-like, GATOR1 complex subunit.
   
 0.940
G3NEV7_GASAC
Uncharacterized protein.
    
 0.929
SZT2
SZT2 subunit of KICSTOR complex.
    
 0.929
G3NHD8_GASAC
Glycogenin 1b.
   
 0.820
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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