Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
G3NHI2_GASACRetinoblastoma binding protein 8-like. (382 aa)    
Predicted Functional Partners:
G3Q1J9_GASAC
Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.
    
 0.889
G3PY55_GASAC
Fibroblast growth factor (acidic) intracellular binding protein a.
    
 
 0.733
G3P470_GASAC
Uncharacterized protein.
    
   0.664
CDK18
Cyclin dependent kinase 18; Belongs to the protein kinase superfamily.
   
 0.602
G3Q6V4_GASAC
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.569
G3N5X5_GASAC
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
    
 0.561
G3N643_GASAC
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
 0.561
G3ND96_GASAC
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
    
 0.561
G3NSR9_GASAC
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
 0.561
CCNE2
Cyclin E2; Belongs to the cyclin family.
    
 0.560
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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