DENND3 protein (Gasterosteus aculeatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

DENND3

DENN domain containing 3. (1285 aa)

Predicted Functional Partners:

G3PWH6_GASAC

0.896

G3PVI1_GASAC

0.716

G3PFB5_GASAC

0.630

G3PJV9_GASAC

0.630

G3Q0F2_GASAC

0.630

G3PSU5_GASAC

0.601

G3Q6L4_GASAC

0.601

G3QCN1_GASAC

0.600

G3P8N3_GASAC

0.583

G3NSA9_GASAC

0.549

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DENND3	G3NSA9_GASAC	ENSGACP00000005280	ENSGACP00000008226	DENN domain containing 3.	Leiomodin 1b (smooth muscle).	0.549
DENND3	G3P8N3_GASAC	ENSGACP00000005280	ENSGACP00000013957	DENN domain containing 3.	Nicalin.	0.583
DENND3	G3PFB5_GASAC	ENSGACP00000005280	ENSGACP00000016289	DENN domain containing 3.	Unc-51 like autophagy activating kinase 1a.	0.630
DENND3	G3PJV9_GASAC	ENSGACP00000005280	ENSGACP00000017889	DENN domain containing 3.	Unc-51 like autophagy activating kinase 2.	0.630
DENND3	G3PSU5_GASAC	ENSGACP00000005280	ENSGACP00000020681	DENN domain containing 3.	DENN/MADD domain containing 5A.	0.601
DENND3	G3PVI1_GASAC	ENSGACP00000005280	ENSGACP00000021618	DENN domain containing 3.	Uncharacterized protein.	0.716
DENND3	G3PWH6_GASAC	ENSGACP00000005280	ENSGACP00000021965	DENN domain containing 3.	RAB12, member RAS oncogene family.	0.896
DENND3	G3Q0F2_GASAC	ENSGACP00000005280	ENSGACP00000023344	DENN domain containing 3.	Unc-51 like autophagy activating kinase 1.	0.630
DENND3	G3Q6L4_GASAC	ENSGACP00000005280	ENSGACP00000025524	DENN domain containing 3.	DENN/MADD domain containing 5B.	0.601
DENND3	G3QCN1_GASAC	ENSGACP00000005280	ENSGACP00000027647	DENN domain containing 3.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.600
G3NSA9_GASAC	DENND3	ENSGACP00000008226	ENSGACP00000005280	Leiomodin 1b (smooth muscle).	DENN domain containing 3.	0.549
G3NSA9_GASAC	G3P8N3_GASAC	ENSGACP00000008226	ENSGACP00000013957	Leiomodin 1b (smooth muscle).	Nicalin.	0.470
G3P8N3_GASAC	DENND3	ENSGACP00000013957	ENSGACP00000005280	Nicalin.	DENN domain containing 3.	0.583
G3P8N3_GASAC	G3NSA9_GASAC	ENSGACP00000013957	ENSGACP00000008226	Nicalin.	Leiomodin 1b (smooth muscle).	0.470
G3PFB5_GASAC	DENND3	ENSGACP00000016289	ENSGACP00000005280	Unc-51 like autophagy activating kinase 1a.	DENN domain containing 3.	0.630
G3PFB5_GASAC	G3PJV9_GASAC	ENSGACP00000016289	ENSGACP00000017889	Unc-51 like autophagy activating kinase 1a.	Unc-51 like autophagy activating kinase 2.	0.903
G3PFB5_GASAC	G3Q0F2_GASAC	ENSGACP00000016289	ENSGACP00000023344	Unc-51 like autophagy activating kinase 1a.	Unc-51 like autophagy activating kinase 1.	0.903
G3PJV9_GASAC	DENND3	ENSGACP00000017889	ENSGACP00000005280	Unc-51 like autophagy activating kinase 2.	DENN domain containing 3.	0.630
G3PJV9_GASAC	G3PFB5_GASAC	ENSGACP00000017889	ENSGACP00000016289	Unc-51 like autophagy activating kinase 2.	Unc-51 like autophagy activating kinase 1a.	0.903
G3PJV9_GASAC	G3Q0F2_GASAC	ENSGACP00000017889	ENSGACP00000023344	Unc-51 like autophagy activating kinase 2.	Unc-51 like autophagy activating kinase 1.	0.900