| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| G3NKK1_GASAC | G3NME7_GASAC | ENSGACP00000005864 | ENSGACP00000006510 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | MMS19 homolog, cytosolic iron-sulfur assembly component. | 0.926 |
| G3NKK1_GASAC | G3NR60_GASAC | ENSGACP00000005864 | ENSGACP00000007826 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Elongator acetyltransferase complex subunit 2. | 0.998 |
| G3NKK1_GASAC | G3P882_GASAC | ENSGACP00000005864 | ENSGACP00000013806 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | KTI12 chromatin associated homolog. | 0.963 |
| G3NKK1_GASAC | G3P8U4_GASAC | ENSGACP00000005864 | ENSGACP00000014014 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Diphthamide biosynthesis 3. | 0.960 |
| G3NKK1_GASAC | G3PGH7_GASAC | ENSGACP00000005864 | ENSGACP00000016701 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Elongator acetyltransferase complex subunit 6. | 0.990 |
| G3NKK1_GASAC | G3PU70_GASAC | ENSGACP00000005864 | ENSGACP00000021157 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Elongator acetyltransferase complex subunit 4. | 0.998 |
| G3NKK1_GASAC | G3PX47_GASAC | ENSGACP00000005864 | ENSGACP00000022186 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | 0.999 |
| G3NKK1_GASAC | G3Q6Y2_GASAC | ENSGACP00000005864 | ENSGACP00000025642 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Elongator acetyltransferase complex subunit 5. | 0.990 |
| G3NKK1_GASAC | MOCS3 | ENSGACP00000005864 | ENSGACP00000009233 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.924 |
| G3NKK1_GASAC | URM1 | ENSGACP00000005864 | ENSGACP00000022979 | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically [...] | 0.928 |
| G3NME7_GASAC | G3NKK1_GASAC | ENSGACP00000006510 | ENSGACP00000005864 | MMS19 homolog, cytosolic iron-sulfur assembly component. | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | 0.926 |
| G3NR60_GASAC | G3NKK1_GASAC | ENSGACP00000007826 | ENSGACP00000005864 | Elongator acetyltransferase complex subunit 2. | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | 0.998 |
| G3NR60_GASAC | G3PGH7_GASAC | ENSGACP00000007826 | ENSGACP00000016701 | Elongator acetyltransferase complex subunit 2. | Elongator acetyltransferase complex subunit 6. | 0.991 |
| G3NR60_GASAC | G3PU70_GASAC | ENSGACP00000007826 | ENSGACP00000021157 | Elongator acetyltransferase complex subunit 2. | Elongator acetyltransferase complex subunit 4. | 0.998 |
| G3NR60_GASAC | G3PX47_GASAC | ENSGACP00000007826 | ENSGACP00000022186 | Elongator acetyltransferase complex subunit 2. | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. | 0.998 |
| G3NR60_GASAC | G3Q6Y2_GASAC | ENSGACP00000007826 | ENSGACP00000025642 | Elongator acetyltransferase complex subunit 2. | Elongator acetyltransferase complex subunit 5. | 0.991 |
| G3NR60_GASAC | MOCS3 | ENSGACP00000007826 | ENSGACP00000009233 | Elongator acetyltransferase complex subunit 2. | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] | 0.440 |
| G3NR60_GASAC | URM1 | ENSGACP00000007826 | ENSGACP00000022979 | Elongator acetyltransferase complex subunit 2. | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically [...] | 0.405 |
| G3P882_GASAC | G3NKK1_GASAC | ENSGACP00000013806 | ENSGACP00000005864 | KTI12 chromatin associated homolog. | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. | 0.963 |
| G3P882_GASAC | G3P8U4_GASAC | ENSGACP00000013806 | ENSGACP00000014014 | KTI12 chromatin associated homolog. | Diphthamide biosynthesis 3. | 0.944 |
