Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
G3NKK9_GASACTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (399 aa)    
Predicted Functional Partners:
G3NRM5_GASAC
Catenin (cadherin-associated protein), beta 1.
    
 0.993
G3NSY0_GASAC
Uncharacterized protein.
    
 
 0.991
G3P402_GASAC
Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.
    
 
 0.987
G3Q3M3_GASAC
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
    
 
 0.987
G3Q3M8_GASAC
Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.
    
 
 0.983
G3N6F8_GASAC
Prefoldin 5.
   
 
 0.982
G3NU10_GASAC
Sp1 transcription factor.
    
 
 0.980
G3P206_GASAC
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
    
 
 0.980
HDAC3
Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    
 
 0.980
G3Q9Z8_GASAC
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
    
 
 0.980
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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