Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
G3NKX2_GASACFibroblast growth factor receptor. (772 aa)    
Predicted Functional Partners:
G3NI51_GASAC
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.976
G3Q2H2_GASAC
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
    
 0.971
G3QBY8_GASAC
Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]
    
 0.971
G3Q8T2_GASAC
Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.
    
 0.970
G3PDD6_GASAC
Son of sevenless homolog 2 (Drosophila).
    
 0.969
G3Q979_GASAC
Son of sevenless homolog 1 (Drosophila).
    
 0.969
G3PX48_GASAC
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.961
G3PM92_GASAC
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.958
G3Q2J1_GASAC
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.958
G3Q400_GASAC
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 0.958
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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