Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SIKE1Suppressor of IKBKE 1. (213 aa)    
Predicted Functional Partners:
G3N5B5_GASAC
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.963
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
    
 
 0.882
G3P2S5_GASAC
MOB family member 4, phocein.
    
 
 0.875
G3NCT9_GASAC
Chromatin licensing and DNA replication factor 1.
    
   0.799
G3N7Q5_GASAC
Striatin interacting protein 1.
    
 
 0.768
G3NE74_GASAC
Sarcolemma associated protein b.
    
 
 0.768
G3NI33_GASAC
Sarcolemma associated protein a.
    
 
 0.768
G3Q585_GASAC
Striatin interacting protein 2.
    
 
 0.768
G3P3K4_GASAC
Protein phosphatase 2, regulatory subunit A, beta b.
    
 
 0.741
G3NVX1_GASAC
Programmed cell death 10a.
   
 
 0.735
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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