Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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G3NLI8_GASAC1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1281 aa)    
Predicted Functional Partners:
G3PYZ7_GASAC
Receptor protein-tyrosine kinase.
    
 0.981
G3Q1Y8_GASAC
Receptor protein-tyrosine kinase.
    
 0.981
G3Q1P0_GASAC
Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    
 0.975
G3PMN1_GASAC
Kinase insert domain receptor (a type III receptor tyrosine kinase).
    
 0.974
G3NG57_GASAC
Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.
    
 0.968
G3NUY1_GASAC
Growth factor receptor-bound protein 2b.
    
 0.958
G3N4V8_GASAC
Inositol 1,4,5-trisphosphate receptor, type 3.
     
 0.943
G3N6C0_GASAC
Inositol 1,4,5-trisphosphate receptor, type 1a.
     
 0.943
G3PCZ9_GASAC
Inositol 1,4,5-trisphosphate receptor, type 2.
     
 0.943
G3PDW6_GASAC
Inositol 1,4,5-trisphosphate receptor, type 1b.
     
 0.943
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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