VDR protein (Gasterosteus aculeatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

VDR

Vitamin D receptor. (420 aa)

Predicted Functional Partners:

G3NRM9_GASAC

0.931

G3NUA2_GASAC

0.865

G3PFG0_GASAC

0.864

G3QA56_GASAC

0.864

G3NEF1_GASAC

0.860

G3P6N9_GASAC

0.860

G3PR38_GASAC

0.860

G3Q022_GASAC

0.860

RXRB

0.846

G3NZ05_GASAC

0.846

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3NEF1_GASAC	G3NRM9_GASAC	ENSGACP00000003702	ENSGACP00000007996	Nuclear receptor coactivator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.714
G3NEF1_GASAC	G3NUA2_GASAC	ENSGACP00000003702	ENSGACP00000008920	Nuclear receptor coactivator.	Nuclear receptor coactivator 1.	0.586
G3NEF1_GASAC	G3NZ05_GASAC	ENSGACP00000003702	ENSGACP00000010576	Nuclear receptor coactivator.	Retinoid x receptor, beta b.	0.845
G3NEF1_GASAC	G3PFG0_GASAC	ENSGACP00000003702	ENSGACP00000016334	Nuclear receptor coactivator.	Nuclear receptor corepressor 2.	0.647
G3NEF1_GASAC	G3QA56_GASAC	ENSGACP00000003702	ENSGACP00000026772	Nuclear receptor coactivator.	Uncharacterized protein.	0.647
G3NEF1_GASAC	RXRB	ENSGACP00000003702	ENSGACP00000000123	Nuclear receptor coactivator.	Retinoid X receptor beta.	0.845
G3NEF1_GASAC	VDR	ENSGACP00000003702	ENSGACP00000006291	Nuclear receptor coactivator.	Vitamin D receptor.	0.860
G3NRM9_GASAC	G3NEF1_GASAC	ENSGACP00000007996	ENSGACP00000003702	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator.	0.714
G3NRM9_GASAC	G3NUA2_GASAC	ENSGACP00000007996	ENSGACP00000008920	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator 1.	0.714
G3NRM9_GASAC	G3NZ05_GASAC	ENSGACP00000007996	ENSGACP00000010576	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Retinoid x receptor, beta b.	0.918
G3NRM9_GASAC	G3P6N9_GASAC	ENSGACP00000007996	ENSGACP00000013262	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor coactivator 3.	0.715
G3NRM9_GASAC	G3PFG0_GASAC	ENSGACP00000007996	ENSGACP00000016334	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor corepressor 2.	0.731
G3NRM9_GASAC	G3PR38_GASAC	ENSGACP00000007996	ENSGACP00000020073	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	BHLH domain-containing protein.	0.714
G3NRM9_GASAC	G3Q022_GASAC	ENSGACP00000007996	ENSGACP00000023212	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.764
G3NRM9_GASAC	G3QA56_GASAC	ENSGACP00000007996	ENSGACP00000026772	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.730
G3NRM9_GASAC	RXRB	ENSGACP00000007996	ENSGACP00000000123	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Retinoid X receptor beta.	0.918
G3NRM9_GASAC	VDR	ENSGACP00000007996	ENSGACP00000006291	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Vitamin D receptor.	0.931
G3NUA2_GASAC	G3NEF1_GASAC	ENSGACP00000008920	ENSGACP00000003702	Nuclear receptor coactivator 1.	Nuclear receptor coactivator.	0.586
G3NUA2_GASAC	G3NRM9_GASAC	ENSGACP00000008920	ENSGACP00000007996	Nuclear receptor coactivator 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.714
G3NUA2_GASAC	G3NZ05_GASAC	ENSGACP00000008920	ENSGACP00000010576	Nuclear receptor coactivator 1.	Retinoid x receptor, beta b.	0.845