Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
G3NMD5_GASACMitogen-activated protein kinase. (367 aa)    
Predicted Functional Partners:
MAP2K6
Mitogen-activated protein kinase kinase 6.
  
0.991
MAPKAPK2
MAPK activated protein kinase 2; Belongs to the protein kinase superfamily.
  
0.987
G3NEG4_GASAC
MAPK activated protein kinase 2b; Belongs to the protein kinase superfamily.
  
0.987
G3Q6V4_GASAC
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.982
G3P7J5_GASAC
Myocyte enhancer factor 2cb.
    
 0.980
G3NL70_GASAC
Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.
    
 0.979
CDC25B
Cell division cycle 25B.
    
 0.978
G3NSM0_GASAC
Protein kinase domain-containing protein.
   
0.972
G3PBH5_GASAC
Ribosomal protein S6 kinase.
   
 
0.970
G3QA73_GASAC
Ribosomal protein S6 kinase.
   
 
0.970
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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