Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
G3NN10_GASACE3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (372 aa)    
Predicted Functional Partners:
G3NN02_GASAC
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
 
     0.921
G3PHC9_GASAC
HECT domain containing 1.
   
  
 0.738
G3PJ15_GASAC
CULLIN_2 domain-containing protein; Belongs to the cullin family.
   
    0.686
CUL5
Cullin 5; Belongs to the cullin family.
   
    0.686
G3NGY4_GASAC
Ubiquitin conjugating enzyme E2 A, like; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.626
G3PZN1_GASAC
Ubiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.626
G3NX84_GASAC
Thyroid hormone receptor interactor 12.
   
 
 0.596
G3NUU8_GASAC
Mitochondrial intermediate peptidase.
      
 0.589
G3Q4P3_GASAC
Ovo-like zinc finger 1a.
    
 
 0.556
G3NC49_GASAC
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 
 0.516
Your Current Organism:
Gasterosteus aculeatus
NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback
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