G3NVA7_GASAC protein (Gasterosteus aculeatus)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

G3NVA7_GASAC

LisH domain-containing protein. (359 aa)

Predicted Functional Partners:

G3NVA9_GASAC

0.896

PTK7

0.700

G3P835_GASAC

0.636

G3NIY0_GASAC

0.634

G3NK22_GASAC

0.634

G3N9I3_GASAC

0.633

G3Q845_GASAC

0.625

G3P3G3_GASAC

0.624

G3P8P8_GASAC

0.624

G3PE85_GASAC

0.624

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3N9I3_GASAC	G3NIY0_GASAC	ENSGACP00000001973	ENSGACP00000005290	Myb-like, SWIRM and MPN domains 1.	AT rich interactive domain 4A (RBP1-like).	0.804
G3N9I3_GASAC	G3NK22_GASAC	ENSGACP00000001973	ENSGACP00000005684	Myb-like, SWIRM and MPN domains 1.	Translocase of outer mitochondrial membrane 20.	0.804
G3N9I3_GASAC	G3NVA7_GASAC	ENSGACP00000001973	ENSGACP00000009276	Myb-like, SWIRM and MPN domains 1.	LisH domain-containing protein.	0.633
G3N9I3_GASAC	G3NVA9_GASAC	ENSGACP00000001973	ENSGACP00000009278	Myb-like, SWIRM and MPN domains 1.	NPAT_C domain-containing protein.	0.638
G3N9I3_GASAC	G3P835_GASAC	ENSGACP00000001973	ENSGACP00000013759	Myb-like, SWIRM and MPN domains 1.	Uncharacterized protein.	0.482
G3NIY0_GASAC	G3N9I3_GASAC	ENSGACP00000005290	ENSGACP00000001973	AT rich interactive domain 4A (RBP1-like).	Myb-like, SWIRM and MPN domains 1.	0.804
G3NIY0_GASAC	G3NK22_GASAC	ENSGACP00000005290	ENSGACP00000005684	AT rich interactive domain 4A (RBP1-like).	Translocase of outer mitochondrial membrane 20.	0.790
G3NIY0_GASAC	G3NVA7_GASAC	ENSGACP00000005290	ENSGACP00000009276	AT rich interactive domain 4A (RBP1-like).	LisH domain-containing protein.	0.634
G3NIY0_GASAC	G3NVA9_GASAC	ENSGACP00000005290	ENSGACP00000009278	AT rich interactive domain 4A (RBP1-like).	NPAT_C domain-containing protein.	0.634
G3NK22_GASAC	G3N9I3_GASAC	ENSGACP00000005684	ENSGACP00000001973	Translocase of outer mitochondrial membrane 20.	Myb-like, SWIRM and MPN domains 1.	0.804
G3NK22_GASAC	G3NIY0_GASAC	ENSGACP00000005684	ENSGACP00000005290	Translocase of outer mitochondrial membrane 20.	AT rich interactive domain 4A (RBP1-like).	0.790
G3NK22_GASAC	G3NVA7_GASAC	ENSGACP00000005684	ENSGACP00000009276	Translocase of outer mitochondrial membrane 20.	LisH domain-containing protein.	0.634
G3NK22_GASAC	G3NVA9_GASAC	ENSGACP00000005684	ENSGACP00000009278	Translocase of outer mitochondrial membrane 20.	NPAT_C domain-containing protein.	0.634
G3NVA7_GASAC	G3N9I3_GASAC	ENSGACP00000009276	ENSGACP00000001973	LisH domain-containing protein.	Myb-like, SWIRM and MPN domains 1.	0.633
G3NVA7_GASAC	G3NIY0_GASAC	ENSGACP00000009276	ENSGACP00000005290	LisH domain-containing protein.	AT rich interactive domain 4A (RBP1-like).	0.634
G3NVA7_GASAC	G3NK22_GASAC	ENSGACP00000009276	ENSGACP00000005684	LisH domain-containing protein.	Translocase of outer mitochondrial membrane 20.	0.634
G3NVA7_GASAC	G3NVA9_GASAC	ENSGACP00000009276	ENSGACP00000009278	LisH domain-containing protein.	NPAT_C domain-containing protein.	0.896
G3NVA7_GASAC	G3P3G3_GASAC	ENSGACP00000009276	ENSGACP00000012136	LisH domain-containing protein.	MET proto-oncogene, receptor tyrosine kinase.	0.624
G3NVA7_GASAC	G3P835_GASAC	ENSGACP00000009276	ENSGACP00000013759	LisH domain-containing protein.	Uncharacterized protein.	0.636
G3NVA7_GASAC	G3P8P8_GASAC	ENSGACP00000009276	ENSGACP00000013972	LisH domain-containing protein.	Macrophage stimulating 1 receptor a.	0.624

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006261

DNA-templated DNA replication

11 of 92

2.37

9.31

1.49e-22

GO:0000727

Double-strand break repair via break-induced replication

7 of 13

3.02

8.39

1.68e-16

GO:0006268

DNA unwinding involved in DNA replication

7 of 18

2.88

7.91

7.80e-16

GO:0006270

DNA replication initiation

6 of 22

2.72

6.18

1.31e-12

GO:1902969

Mitotic DNA replication

4 of 12

2.81

4.11

2.29e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003697

Single-stranded DNA binding

6 of 81

2.16

3.91

4.50e-09

GO:0003678

DNA helicase activity

5 of 52

2.27

3.56

6.68e-08

GO:0140097

Catalytic activity, acting on DNA

6 of 208

1.75

2.61

3.60e-07

GO:0003688

DNA replication origin binding

3 of 12

2.69

2.58

1.71e-05

GO:0016887

ATP hydrolysis activity

4 of 302

1.41

1.07

0.0030

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071162

CMG complex

7 of 12

3.05

8.84

2.54e-17

GO:0000228

Nuclear chromosome

11 of 138

2.19

8.06

1.60e-21

GO:0042555

MCM complex

5 of 11

2.95

5.83

1.34e-11

GO:0043596

Nuclear replication fork

3 of 20

2.46

2.56

1.48e-05

GO:0031298

Replication fork protection complex

2 of 2

3.29

2.19

0.00011

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32828016

(2020) Generation and characterization of keap1a- and keap1b-knockout zebrafish.

2 of 8

2.69

0.82

0.0328

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7155

DNA replication preinitiation complex, and CDC6 association with the ORC:origin complex

10 of 29

2.83

11.78

2.95e-24

CL:7153

Activation of the pre-replicative complex, and Regulation of DNA-directed DNA polymerase activity

11 of 49

2.64

11.68

1.49e-25

CL:7158

CMG complex

8 of 12

3.11

10.5

1.78e-20

CL:7161

MCM N-terminal domain

4 of 5

3.19

4.66

3.17e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru03030

DNA replication

6 of 36

2.51

5.76

3.00e-12

tru04110

Cell cycle

6 of 126

1.97

3.72

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68962

Activation of the pre-replicative complex

7 of 37

2.57

6.63

5.12e-14

MAP-176187

Activation of ATR in response to replication stress

6 of 39

2.48

5.39

1.55e-11

MAP-69206

G1/S Transition

7 of 139

1.99

4.21

7.97e-11

MAP-69306

DNA Replication

8 of 208

1.87

4.12

1.26e-11

MAP-69239

Synthesis of DNA

7 of 149

1.96

4.1

1.02e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042555

MCM complex

5 of 10

2.99

5.53

5.59e-11

GOCC:0031261

DNA replication preinitiation complex

2 of 6

2.81

1.26

0.0051

GOCC:0032991

Protein-containing complex

9 of 4666

0.57

0.38

0.0202

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

7 of 32

2.63

7.23

4.14e-15

KW-0347

Helicase

5 of 41

2.37

4.27

2.80e-09

KW-0539

Nucleus

8 of 1096

1.15

1.41

7.82e-07

KW-0131

Cell cycle

2 of 25

2.19

1.28

0.0039

KW-0238

DNA-binding

6 of 728

1.2

1.27

5.30e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14551

MCM N-terminal domain

2 of 3

3.11

1.25

0.0055

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027925

MCM N-terminal domain

5 of 6

3.21

5.72

3.47e-11

IPR018525

Mini-chromosome maintenance, conserved site

5 of 6

3.21

5.72

3.47e-11

IPR041562

MCM, AAA-lid domain

5 of 7

3.14

5.7

3.47e-11

IPR033762

MCM OB domain

5 of 7

3.14

5.7

3.47e-11

IPR001208

MCM domain

5 of 7

3.14

5.7

3.47e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00350

Minichromosome maintenance proteins

2 of 2

3.29

1.64

0.0011

SM00382

ATPases associated with a variety of cellular activities

3 of 129

1.66

0.91

0.0142

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