G3PCL7_GASAC protein (Gasterosteus aculeatus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

G3PCL7_GASAC

Glutamate receptor, metabotropic 1b. (1136 aa)

Predicted Functional Partners:

G3P668_GASAC

0.874

HOMER2

0.827

G3NYP0_GASAC

0.816

G3NYS2_GASAC

0.816

G3PD78_GASAC

0.812

AGAP2

0.804

G3P9Y2_GASAC

0.794

G3PCT4_GASAC

0.793

G3PC39_GASAC

0.782

G3PUR9_GASAC

0.782

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP2	G3PCL7_GASAC	ENSGACP00000000769	ENSGACP00000015341	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	Glutamate receptor, metabotropic 1b.	0.804
AGAP2	G3PCT4_GASAC	ENSGACP00000000769	ENSGACP00000015408	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	Glutamate receptor, metabotropic 1a.	0.861
AGAP2	G3PD78_GASAC	ENSGACP00000000769	ENSGACP00000015552	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	0.843
G3NYP0_GASAC	G3NYS2_GASAC	ENSGACP00000010461	ENSGACP00000010493	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha 14a.	0.842
G3NYP0_GASAC	G3PC39_GASAC	ENSGACP00000010461	ENSGACP00000015163	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	0.808
G3NYP0_GASAC	G3PCL7_GASAC	ENSGACP00000010461	ENSGACP00000015341	Uncharacterized protein.	Glutamate receptor, metabotropic 1b.	0.816
G3NYP0_GASAC	G3PCT4_GASAC	ENSGACP00000010461	ENSGACP00000015408	Uncharacterized protein.	Glutamate receptor, metabotropic 1a.	0.869
G3NYP0_GASAC	G3PUR9_GASAC	ENSGACP00000010461	ENSGACP00000021356	Uncharacterized protein.	Uncharacterized protein.	0.842
G3NYS2_GASAC	G3NYP0_GASAC	ENSGACP00000010493	ENSGACP00000010461	Guanine nucleotide binding protein (G protein), alpha 14a.	Uncharacterized protein.	0.842
G3NYS2_GASAC	G3PC39_GASAC	ENSGACP00000010493	ENSGACP00000015163	Guanine nucleotide binding protein (G protein), alpha 14a.	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	0.809
G3NYS2_GASAC	G3PCL7_GASAC	ENSGACP00000010493	ENSGACP00000015341	Guanine nucleotide binding protein (G protein), alpha 14a.	Glutamate receptor, metabotropic 1b.	0.816
G3NYS2_GASAC	G3PCT4_GASAC	ENSGACP00000010493	ENSGACP00000015408	Guanine nucleotide binding protein (G protein), alpha 14a.	Glutamate receptor, metabotropic 1a.	0.865
G3NYS2_GASAC	G3PUR9_GASAC	ENSGACP00000010493	ENSGACP00000021356	Guanine nucleotide binding protein (G protein), alpha 14a.	Uncharacterized protein.	0.712
G3P668_GASAC	G3PCL7_GASAC	ENSGACP00000013091	ENSGACP00000015341	Homer scaffold protein 1b.	Glutamate receptor, metabotropic 1b.	0.874
G3P668_GASAC	G3PCT4_GASAC	ENSGACP00000013091	ENSGACP00000015408	Homer scaffold protein 1b.	Glutamate receptor, metabotropic 1a.	0.908
G3P668_GASAC	HOMER2	ENSGACP00000013091	ENSGACP00000019852	Homer scaffold protein 1b.	Homer scaffold protein 2.	0.869
G3P9Y2_GASAC	G3PCL7_GASAC	ENSGACP00000014406	ENSGACP00000015341	Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2.	Glutamate receptor, metabotropic 1b.	0.794
G3P9Y2_GASAC	G3PCT4_GASAC	ENSGACP00000014406	ENSGACP00000015408	Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2.	Glutamate receptor, metabotropic 1a.	0.794
G3PC39_GASAC	G3NYP0_GASAC	ENSGACP00000015163	ENSGACP00000010461	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	Uncharacterized protein.	0.808
G3PC39_GASAC	G3NYS2_GASAC	ENSGACP00000015163	ENSGACP00000010493	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1.	Guanine nucleotide binding protein (G protein), alpha 14a.	0.809

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Network Stats

number of nodes:

5

number of edges:

6

average node degree:

2.4

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.214

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051045

Negative regulation of membrane protein ectodomain proteolysis

4 of 5

3.57

6.73

4.23e-10

GO:0009725

Response to hormone

4 of 416

1.65

1.82

0.00033

GO:0034097

Response to cytokine

4 of 431

1.63

1.8

0.00035

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008191

Metalloendopeptidase inhibitor activity

4 of 13

3.16

6.05

2.64e-09

GO:0002020

Protease binding

4 of 73

2.41

3.98

7.50e-07

GO:0008270

Zinc ion binding

4 of 778

1.38

1.25

0.0021

GO:0046872

Metal ion binding

5 of 4369

0.73

0.43

0.0489

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031012

Extracellular matrix

5 of 521

1.65

2.37

7.39e-06

GO:0005576

Extracellular region

5 of 2032

1.06

0.9

0.0022

GO:0005615

Extracellular space

4 of 1283

1.16

0.82

0.0142

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23867

Hemopexin-like repeats, and P domain

5 of 35

2.82

6.9

5.91e-11

CL:23868

Hemopexin-like repeats, and Protease inhibitor I35 (TIMP)

4 of 29

2.81

5.38

1.42e-08

CL:23874

Peptidoglycan binding-like, and Protease inhibitor I35 (TIMP)

3 of 15

2.97

3.92

2.83e-06

CL:23876

Peptidase M10A, cysteine switch, zinc binding site, and Tissue inhibitor of metalloproteinase, conserved site

2 of 10

2.97

2.04

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1592389

Activation of Matrix Metalloproteinases

3 of 57

2.39

2.42

0.00027

MAP-1474228

Degradation of the extracellular matrix

3 of 198

1.85

1.43

0.0052

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000088

Cardiovascular system

3 of 531

1.42

1.39

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0964

Secreted

4 of 281

1.82

2.42

3.67e-05

KW-1015

Disulfide bond

5 of 1389

1.22

1.31

0.00013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027465

Proteinase inhibitor I35b (TIMP), C-terminal

4 of 4

3.67

6.95

2.16e-10

IPR001820

Protease inhibitor I35 (TIMP)

4 of 4

3.67

6.95

2.16e-10

IPR030490

Tissue inhibitor of metalloproteinase, conserved site

3 of 3

3.67

4.94

1.44e-07

IPR001134

Netrin domain

4 of 33

2.75

4.9

6.79e-08

IPR008993

Tissue inhibitor of metalloproteinases-like, OB-fold

4 of 34

2.74

4.89

6.79e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00206

Tissue inhibitor of metalloproteinase family.

4 of 4

3.67

7.64

2.29e-11

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