G3PHR6_GASAC protein (Gasterosteus aculeatus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

G3PHR6_GASAC

Matrilin 3b. (406 aa)

Predicted Functional Partners:

G3Q8G8_GASAC

0.819

G3N415_GASAC

0.738

G3PTN1_GASAC

0.728

G3PVZ0_GASAC

0.706

PTK7

0.697

MFAP2

0.689

G3ND14_GASAC

0.681

G3PH53_GASAC

0.664

G3NB77_GASAC

0.663

G3P0Y5_GASAC

0.654

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3N415_GASAC	G3PHR6_GASAC	ENSGACP00000000032	ENSGACP00000017142	LAG1_DNAbind domain-containing protein.	Matrilin 3b.	0.738
G3N415_GASAC	G3PTN1_GASAC	ENSGACP00000000032	ENSGACP00000020967	LAG1_DNAbind domain-containing protein.	Recombination signal binding protein for immunoglobulin kappa J region a.	0.860
G3NB77_GASAC	G3ND14_GASAC	ENSGACP00000002573	ENSGACP00000003214	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b.	0.740
G3NB77_GASAC	G3P0Y5_GASAC	ENSGACP00000002573	ENSGACP00000011258	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.716
G3NB77_GASAC	G3PHR6_GASAC	ENSGACP00000002573	ENSGACP00000017142	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	Matrilin 3b.	0.663
G3NB77_GASAC	G3PVZ0_GASAC	ENSGACP00000002573	ENSGACP00000021779	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	Info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a.	0.739
G3NB77_GASAC	G3Q8G8_GASAC	ENSGACP00000002573	ENSGACP00000026182	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	Lumican.	0.457
G3NB77_GASAC	PTK7	ENSGACP00000002573	ENSGACP00000005294	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.957
G3ND14_GASAC	G3NB77_GASAC	ENSGACP00000003214	ENSGACP00000002573	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b.	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	0.740
G3ND14_GASAC	G3P0Y5_GASAC	ENSGACP00000003214	ENSGACP00000011258	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b.	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	0.717
G3ND14_GASAC	G3PHR6_GASAC	ENSGACP00000003214	ENSGACP00000017142	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b.	Matrilin 3b.	0.681
G3ND14_GASAC	G3PVZ0_GASAC	ENSGACP00000003214	ENSGACP00000021779	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b.	Info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a.	0.777
G3ND14_GASAC	PTK7	ENSGACP00000003214	ENSGACP00000005294	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.957
G3P0Y5_GASAC	G3NB77_GASAC	ENSGACP00000011258	ENSGACP00000002573	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b.	0.716
G3P0Y5_GASAC	G3ND14_GASAC	ENSGACP00000011258	ENSGACP00000003214	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1b.	0.717
G3P0Y5_GASAC	G3PHR6_GASAC	ENSGACP00000011258	ENSGACP00000017142	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	Matrilin 3b.	0.654
G3P0Y5_GASAC	G3PVZ0_GASAC	ENSGACP00000011258	ENSGACP00000021779	Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family.	Info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a.	0.735
G3PH53_GASAC	G3PHR6_GASAC	ENSGACP00000016928	ENSGACP00000017142	Transforming growth factor beta; Belongs to the TGF-beta family.	Matrilin 3b.	0.664
G3PH53_GASAC	G3Q8G8_GASAC	ENSGACP00000016928	ENSGACP00000026182	Transforming growth factor beta; Belongs to the TGF-beta family.	Lumican.	0.768
G3PH53_GASAC	PTK7	ENSGACP00000016928	ENSGACP00000005294	Transforming growth factor beta; Belongs to the TGF-beta family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.523

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.907

expected number of edges:

10

PPI enrichment p-value:

5.55e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030042

Actin filament depolymerization

3 of 11

2.71

1.91

0.00032

GO:0051014

Actin filament severing

3 of 16

2.55

1.85

0.00038

GO:0030043

Actin filament fragmentation

2 of 3

3.1

1.37

0.0034

GO:0030036

Actin cytoskeleton organization

6 of 512

1.35

1.27

0.00038

GO:0022604

Regulation of cell morphogenesis

4 of 196

1.59

1.14

0.0034

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003779

Actin binding

5 of 498

1.28

0.85

0.0087

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

5 of 376

1.4

1.19

0.0011

GO:0005925

Focal adhesion

3 of 112

1.7

0.97

0.0109

GO:0005856

Cytoskeleton

7 of 1877

0.85

0.6

0.0073

GO:0043232

Intracellular non-membrane-bounded organelle

8 of 3620

0.62

0.4

0.0212

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2568

ADF/Cofilin, and Sema3A PAK dependent Axon repulsion

3 of 6

2.98

2.42

4.03e-05

CL:2418

Mixed, incl. Dual specificity phosphatase, catalytic domain, and MAP kinase activity

4 of 89

1.93

1.83

0.00018

CL:1933

Parvin, and Integrin-linked protein kinase, pseudokinase domain

2 of 7

2.73

1.2

0.0067

CL:1398

Mixed, incl. Phenylalanine zipper, and Insulin receptor, trans-membrane domain

2 of 8

2.67

1.18

0.0071

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446388

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

3 of 11

2.71

2.27

6.62e-05

MAP-9020591

Interleukin-12 signaling

3 of 15

2.58

2.23

7.41e-05

MAP-447115

Interleukin-12 family signaling

3 of 21

2.43

2.09

0.00012

MAP-399954

Sema3A PAK dependent Axon repulsion

3 of 26

2.34

1.99

0.00017

MAP-446353

Cell-extracellular matrix interactions

3 of 32

2.25

1.89

0.00024

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0009

Actin-binding

3 of 120

1.67

0.97

0.0106

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017904

ADF/Cofilin

3 of 3

3.28

2.67

1.53e-05

IPR002108

Actin-depolymerising factor homology domain

3 of 12

2.67

2.05

0.00017

IPR029006

ADF-H/Gelsolin-like domain superfamily

3 of 30

2.28

1.52

0.0014

IPR028433

Parvin

2 of 3

3.1

1.31

0.0044

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00102

Actin depolymerisation factor/cofilin -like domains

3 of 11

2.71

2.45

3.06e-05

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