G3PT73_GASAC protein (Gasterosteus aculeatus)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

G3PT73_GASAC

Copine VII. (572 aa)

Predicted Functional Partners:

G3NEE6_GASAC

0.679

G3PU55_GASAC

0.646

G3Q5X0_GASAC

0.594

G3N7W0_GASAC

0.545

G3N996_GASAC

0.524

G3NFV1_GASAC

0.524

G3NK63_GASAC

0.524

PI4KB

0.524

G3PJV3_GASAC

0.517

MTMR4

0.517

Your Current Organism:

Gasterosteus aculeatus

NCBI taxonomy Id: 69293
Other names: G. aculeatus, three spined stickleback, three-spined stickleback

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G3N7W0_GASAC	G3PJV3_GASAC	ENSGACP00000001394	ENSGACP00000017883	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Myotubularin related protein 3.	0.597
G3N7W0_GASAC	G3PT73_GASAC	ENSGACP00000001394	ENSGACP00000020809	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Copine VII.	0.545
G3N7W0_GASAC	MTMR4	ENSGACP00000001394	ENSGACP00000026741	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Myotubularin related protein 4.	0.587
G3N996_GASAC	G3NFV1_GASAC	ENSGACP00000001886	ENSGACP00000004206	SAC domain-containing protein.	PIK helical domain-containing protein.	0.833
G3N996_GASAC	G3NK63_GASAC	ENSGACP00000001886	ENSGACP00000005725	SAC domain-containing protein.	SAC1 like phosphatidylinositide phosphatase b.	0.850
G3N996_GASAC	G3PJV3_GASAC	ENSGACP00000001886	ENSGACP00000017883	SAC domain-containing protein.	Myotubularin related protein 3.	0.858
G3N996_GASAC	G3PT73_GASAC	ENSGACP00000001886	ENSGACP00000020809	SAC domain-containing protein.	Copine VII.	0.524
G3N996_GASAC	G3Q5X0_GASAC	ENSGACP00000001886	ENSGACP00000025276	SAC domain-containing protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.903
G3N996_GASAC	MTMR4	ENSGACP00000001886	ENSGACP00000026741	SAC domain-containing protein.	Myotubularin related protein 4.	0.858
G3N996_GASAC	PI4KB	ENSGACP00000001886	ENSGACP00000013110	SAC domain-containing protein.	Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family.	0.905
G3NEE6_GASAC	G3PT73_GASAC	ENSGACP00000003697	ENSGACP00000020809	Ribonuclease H2, subunit B.	Copine VII.	0.679
G3NEE6_GASAC	G3PU55_GASAC	ENSGACP00000003697	ENSGACP00000021142	Ribonuclease H2, subunit B.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.997
G3NFV1_GASAC	G3N996_GASAC	ENSGACP00000004206	ENSGACP00000001886	PIK helical domain-containing protein.	SAC domain-containing protein.	0.833
G3NFV1_GASAC	G3NK63_GASAC	ENSGACP00000004206	ENSGACP00000005725	PIK helical domain-containing protein.	SAC1 like phosphatidylinositide phosphatase b.	0.833
G3NFV1_GASAC	G3PJV3_GASAC	ENSGACP00000004206	ENSGACP00000017883	PIK helical domain-containing protein.	Myotubularin related protein 3.	0.731
G3NFV1_GASAC	G3PT73_GASAC	ENSGACP00000004206	ENSGACP00000020809	PIK helical domain-containing protein.	Copine VII.	0.524
G3NFV1_GASAC	G3Q5X0_GASAC	ENSGACP00000004206	ENSGACP00000025276	PIK helical domain-containing protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.867
G3NFV1_GASAC	MTMR4	ENSGACP00000004206	ENSGACP00000026741	PIK helical domain-containing protein.	Myotubularin related protein 4.	0.731
G3NK63_GASAC	G3N996_GASAC	ENSGACP00000005725	ENSGACP00000001886	SAC1 like phosphatidylinositide phosphatase b.	SAC domain-containing protein.	0.850
G3NK63_GASAC	G3NFV1_GASAC	ENSGACP00000005725	ENSGACP00000004206	SAC1 like phosphatidylinositide phosphatase b.	PIK helical domain-containing protein.	0.833

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.848

expected number of edges:

10

PPI enrichment p-value:

0.00523

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000121

Regulation of removal of superoxide radicals

2 of 4

3.01

1.1

0.0106

GO:0035998

7,8-dihydroneopterin 3-triphosphate biosynthetic process

2 of 2

3.31

1.1

0.0106

GO:0051000

Positive regulation of nitric-oxide synthase activity

2 of 6

2.83

1.06

0.0123

GO:0046654

Tetrahydrofolate biosynthetic process

2 of 6

2.83

1.06

0.0123

GO:0042416

Dopamine biosynthetic process

2 of 6

2.83

1.06

0.0123

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003934

GTP cyclohydrolase I activity

2 of 2

3.31

1.37

0.0034

GO:0051019

Mitogen-activated protein kinase binding

2 of 15

2.43

0.94

0.0192

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0012505

Endomembrane system

9 of 3126

0.77

0.62

0.0011

GO:0031984

Organelle subcompartment

5 of 1041

0.99

0.62

0.0168

GO:0031410

Cytoplasmic vesicle

6 of 1397

0.94

0.61

0.0132

GO:0005768

Endosome

4 of 625

1.11

0.61

0.0311

GO:0031090

Organelle membrane

7 of 2592

0.74

0.49

0.0153

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33051

Mixed, incl. Reticulon, and Xylanase inhibitor C-terminal

4 of 11

2.87

3.64

1.91e-07

CL:33053

Reticulon, and Xylanase inhibitor C-terminal

3 of 6

3.01

2.89

5.47e-06

CL:26512

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

2 of 5

2.91

1.46

0.0023

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1474151

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

2 of 8

2.71

0.99

0.0164

MAP-193634

Axonal growth inhibition (RHOA activation)

2 of 12

2.53

0.98

0.0166

MAP-193697

p75NTR regulates axonogenesis

2 of 14

2.46

0.97

0.0166

MAP-8978934

Metabolism of cofactors

2 of 23

2.25

0.85

0.0273

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034615

GCH1 complex

2 of 3

3.13

1.38

0.0033

GOCC:0014802

Terminal cisterna

2 of 7

2.76

1.22

0.0060

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0064

Aspartyl protease

2 of 18

2.35

1.0

0.0146

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14541

Xylanase inhibitor C-terminal

2 of 3

3.13

1.41

0.0029

PF01227

GTP cyclohydrolase I

2 of 2

3.31

1.41

0.0029

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