node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | G3N781_GASAC | ENSGACP00000002941 | ENSGACP00000001158 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | FA complementation group D2. | 0.446 |
FEN1 | G3NBZ1_GASAC | ENSGACP00000002941 | ENSGACP00000002840 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Exonuclease 1. | 0.884 |
FEN1 | G3NSY0_GASAC | ENSGACP00000002941 | ENSGACP00000008448 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.661 |
FEN1 | G3P3Z7_GASAC | ENSGACP00000002941 | ENSGACP00000012320 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.970 |
FEN1 | G3P4E5_GASAC | ENSGACP00000002941 | ENSGACP00000012468 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.930 |
FEN1 | G3PDW8_GASAC | ENSGACP00000002941 | ENSGACP00000015792 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.809 |
FEN1 | G3PT40_GASAC | ENSGACP00000002941 | ENSGACP00000020776 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Zgc:110269. | 0.850 |
FEN1 | G3Q5Y7_GASAC | ENSGACP00000002941 | ENSGACP00000025293 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | POLAc domain-containing protein. | 0.768 |
G3N781_GASAC | FEN1 | ENSGACP00000001158 | ENSGACP00000002941 | FA complementation group D2. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.446 |
G3N781_GASAC | G3NBZ1_GASAC | ENSGACP00000001158 | ENSGACP00000002840 | FA complementation group D2. | Exonuclease 1. | 0.706 |
G3N781_GASAC | G3NSY0_GASAC | ENSGACP00000001158 | ENSGACP00000008448 | FA complementation group D2. | Uncharacterized protein. | 0.946 |
G3N781_GASAC | G3P3Z7_GASAC | ENSGACP00000001158 | ENSGACP00000012320 | FA complementation group D2. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.597 |
G3N781_GASAC | G3P4E5_GASAC | ENSGACP00000001158 | ENSGACP00000012468 | FA complementation group D2. | Uncharacterized protein. | 0.992 |
G3N781_GASAC | G3PCM8_GASAC | ENSGACP00000001158 | ENSGACP00000015352 | FA complementation group D2. | FA complementation group I. | 0.999 |
G3N781_GASAC | G3PDW8_GASAC | ENSGACP00000001158 | ENSGACP00000015792 | FA complementation group D2. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.418 |
G3N781_GASAC | G3PT40_GASAC | ENSGACP00000001158 | ENSGACP00000020776 | FA complementation group D2. | Zgc:110269. | 0.446 |
G3N781_GASAC | G3Q5Y7_GASAC | ENSGACP00000001158 | ENSGACP00000025293 | FA complementation group D2. | POLAc domain-containing protein. | 0.853 |
G3NBZ1_GASAC | FEN1 | ENSGACP00000002840 | ENSGACP00000002941 | Exonuclease 1. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.884 |
G3NBZ1_GASAC | G3N781_GASAC | ENSGACP00000002840 | ENSGACP00000001158 | Exonuclease 1. | FA complementation group D2. | 0.706 |
G3NBZ1_GASAC | G3NSY0_GASAC | ENSGACP00000002840 | ENSGACP00000008448 | Exonuclease 1. | Uncharacterized protein. | 0.934 |