Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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CBR_g74DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (257 aa)    
Predicted Functional Partners:
CBR_g45436
DUF1767 domain-containing protein.
     
 0.977
CBR_g34731
Uncharacterized protein.
  
 0.972
CBR_g26360
3'-5' exonuclease domain-containing protein.
  
 0.963
CBR_g39230
Uncharacterized protein.
  
 0.963
CBR_g41660
DUF1767 domain-containing protein.
    
 0.953
CBR_g12756
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.949
CBR_g17098
Uncharacterized protein.
    
 0.945
CBR_g23266
Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses.
    
 0.941
CBR_g49975
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.925
CBR_g44528
ERCC4 domain-containing protein.
    
 0.910
Your Current Organism:
Chara braunii
NCBI taxonomy Id: 69332
Other names: C. braunii
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