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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBR_g74DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (257 aa)    
Predicted Functional Partners:
CBR_g26360
3'-5' exonuclease domain-containing protein.
  
 0.995
CBR_g39230
Uncharacterized protein.
  
 0.995
CBR_g41660
DUF1767 domain-containing protein.
    
 0.951
CBR_g44539
AAA_23 domain-containing protein.
  
 0.817
CBR_g34731
Uncharacterized protein.
  
 0.816
CBR_g44528
ERCC4 domain-containing protein.
    
 0.814
CBR_g470
PPIase cyclophilin-type domain-containing protein.
    
 0.787
CBR_g39228
ERCC4 domain-containing protein.
    
 0.787
CBR_g69645
Uncharacterized protein.
    
 0.787
CBR_g49975
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
  
 0.779
Your Current Organism:
Chara braunii
NCBI taxonomy Id: 69332
Other names: C. braunii
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