CBR_g6393 protein (Chara braunii) - STRING interaction network

Nodes:

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

CBR_g6393

F-box domain-containing protein. (370 aa)

Predicted Functional Partners:

CBR_g47955

0.673

CBR_g18638

0.624

CBR_g31132

0.617

CBR_g51475

0.585

CBR_g4422

0.585

CBR_g3680

0.581

CBR_g8783

0.581

CBR_g22465

0.581

CBR_g61481

0.563

CBR_g36665

0.563

Your Current Organism:

Chara braunii

NCBI taxonomy Id: 69332
Other names: C. braunii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBR_g18638	CBR_g31132	A0A388JTG0	A0A388LEN1	Peptidase C50 domain-containing protein.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.977
CBR_g18638	CBR_g36665	A0A388JTG0	A0A388LL47	Peptidase C50 domain-containing protein.	Uncharacterized protein.	0.477
CBR_g18638	CBR_g61481	A0A388JTG0	A0A388K8Q9	Peptidase C50 domain-containing protein.	Uncharacterized protein.	0.477
CBR_g18638	CBR_g6393	A0A388JTG0	A0A388KJN5	Peptidase C50 domain-containing protein.	F-box domain-containing protein.	0.624
CBR_g22465	CBR_g4422	A0A388L2Q3	A0A388KHQ2	Uncharacterized protein.	Autophagy-related protein.	0.664
CBR_g22465	CBR_g47955	A0A388L2Q3	A0A388M1V2	Uncharacterized protein.	Uncharacterized protein.	0.434
CBR_g22465	CBR_g51475	A0A388L2Q3	A0A388K6M5	Uncharacterized protein.	Autophagy-related protein.	0.664
CBR_g22465	CBR_g6393	A0A388L2Q3	A0A388KJN5	Uncharacterized protein.	F-box domain-containing protein.	0.581
CBR_g31132	CBR_g18638	A0A388LEN1	A0A388JTG0	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Peptidase C50 domain-containing protein.	0.977
CBR_g31132	CBR_g36665	A0A388LEN1	A0A388LL47	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Uncharacterized protein.	0.585
CBR_g31132	CBR_g47955	A0A388LEN1	A0A388M1V2	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Uncharacterized protein.	0.599
CBR_g31132	CBR_g61481	A0A388LEN1	A0A388K8Q9	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Uncharacterized protein.	0.585
CBR_g31132	CBR_g6393	A0A388LEN1	A0A388KJN5	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	F-box domain-containing protein.	0.617
CBR_g36665	CBR_g18638	A0A388LL47	A0A388JTG0	Uncharacterized protein.	Peptidase C50 domain-containing protein.	0.477
CBR_g36665	CBR_g31132	A0A388LL47	A0A388LEN1	Uncharacterized protein.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.585
CBR_g36665	CBR_g47955	A0A388LL47	A0A388M1V2	Uncharacterized protein.	Uncharacterized protein.	0.987
CBR_g36665	CBR_g61481	A0A388LL47	A0A388K8Q9	Uncharacterized protein.	Uncharacterized protein.	0.538
CBR_g36665	CBR_g6393	A0A388LL47	A0A388KJN5	Uncharacterized protein.	F-box domain-containing protein.	0.563
CBR_g3680	CBR_g4422	A0A388KG12	A0A388KHQ2	Uncharacterized protein.	Autophagy-related protein.	0.664
CBR_g3680	CBR_g47955	A0A388KG12	A0A388M1V2	Uncharacterized protein.	Uncharacterized protein.	0.434

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.851

expected number of edges:

10

PPI enrichment p-value:

3.1e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043953

Protein transport by the Tat complex

6 of 6

2.4

4.53

8.38e-10

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008320

Protein transmembrane transporter activity

6 of 14

2.03

3.48

1.93e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033281

TAT protein transport complex

6 of 6

2.4

4.97

8.51e-11

GO:0005887

Integral component of plasma membrane

6 of 55

1.44

1.93

1.18e-06

GO:0032991

Protein-containing complex

7 of 219

0.9

0.84

0.00011

GO:0071944

Cell periphery

9 of 600

0.57

0.47

0.00074

GO:0005886

Plasma membrane

8 of 507

0.6

0.46

0.0021

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28848502

(2017) In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity.

4 of 4

2.4

2.93

2.31e-06

PMID:24465566

(2014) Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications.

4 of 4

2.4

2.93

2.31e-06

PMID:26880113

(2016) Inferences from tip-calibrated phylogenies: a review and a practical guide.

2 of 2

2.4

1.17

0.0070

PMID:24236045

(2013) Diversity and evolution of bacterial twin arginine translocase protein, TatC, reveals a protein secretion system that is evolving to fit its environmental niche.

2 of 7

1.85

0.79

0.0313

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4521

TAT protein transport complex

6 of 6

2.4

4.78

2.20e-10

CL:4509

TAT protein transport complex, and Copper ion binding

7 of 12

2.16

4.69

4.33e-11

CL:4352

Mixed, incl. Efflux transmembrane transporter activity, and RND efflux pump, membrane fusion protein

8 of 94

1.33

1.89

8.44e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mfa03060

Protein export

6 of 19

1.9

3.32

1.23e-08

mfa03070

Bacterial secretion system

6 of 33

1.66

2.59

1.10e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033281

TAT protein transport complex

6 of 6

2.4

4.83

1.70e-10

GOCC:0005886

Plasma membrane

7 of 353

0.7

0.49

0.0077

GOCC:0032991

Protein-containing complex

7 of 443

0.6

0.38

0.0261

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

6 of 14

2.03

3.66

6.34e-09

KW-0997

Cell inner membrane

7 of 108

1.21

1.44

3.85e-06

KW-1133

Transmembrane helix

8 of 566

0.55

0.39

0.0112

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00902

Sec-independent protein translocase protein (TatC)

2 of 2

2.4

0.75

0.0425

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003369

Sec-independent protein translocase protein TatA/B/E

4 of 4

2.4

2.59

1.13e-05

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