CBR_g39157 protein (Chara braunii) - STRING interaction network

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

CBR_g39157

HIT domain-containing protein. (380 aa)

Predicted Functional Partners:

CBR_g36815

0.877

CBR_g36817

0.877

CBR_g24123

0.874

CBR_g61459

0.755

CBR_g28654

0.728

CBR_g3480

0.704

CBR_g27979

0.704

CBR_g52240

0.704

CBR_g53663

0.704

CBR_g4586

0.698

Your Current Organism:

Chara braunii

NCBI taxonomy Id: 69332
Other names: C. braunii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBR_g24123	CBR_g27979	A0A388L5V1	A0A388L8X9	PAPS_reduct domain-containing protein.	Uncharacterized protein.	0.516
CBR_g24123	CBR_g28654	A0A388L5V1	A0A388L9H5	PAPS_reduct domain-containing protein.	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.	0.997
CBR_g24123	CBR_g3480	A0A388L5V1	A0A388JQZ7	PAPS_reduct domain-containing protein.	Uncharacterized protein.	0.516
CBR_g24123	CBR_g36815	A0A388L5V1	A0A388LLR8	PAPS_reduct domain-containing protein.	Uncharacterized protein.	0.944
CBR_g24123	CBR_g36817	A0A388L5V1	A0A388LLU3	PAPS_reduct domain-containing protein.	Oxidored_molyb domain-containing protein.	0.944
CBR_g24123	CBR_g39157	A0A388L5V1	A0A388LR25	PAPS_reduct domain-containing protein.	HIT domain-containing protein.	0.874
CBR_g24123	CBR_g4586	A0A388L5V1	A0A388KI81	PAPS_reduct domain-containing protein.	Uncharacterized protein.	0.985
CBR_g24123	CBR_g52240	A0A388L5V1	A0A388MA38	PAPS_reduct domain-containing protein.	Uncharacterized protein.	0.516
CBR_g24123	CBR_g53663	A0A388L5V1	A0A388MB26	PAPS_reduct domain-containing protein.	Uncharacterized protein.	0.516
CBR_g27979	CBR_g24123	A0A388L8X9	A0A388L5V1	Uncharacterized protein.	PAPS_reduct domain-containing protein.	0.516
CBR_g27979	CBR_g39157	A0A388L8X9	A0A388LR25	Uncharacterized protein.	HIT domain-containing protein.	0.704
CBR_g28654	CBR_g24123	A0A388L9H5	A0A388L5V1	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.	PAPS_reduct domain-containing protein.	0.997
CBR_g28654	CBR_g36815	A0A388L9H5	A0A388LLR8	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.	Uncharacterized protein.	0.827
CBR_g28654	CBR_g36817	A0A388L9H5	A0A388LLU3	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.	Oxidored_molyb domain-containing protein.	0.827
CBR_g28654	CBR_g39157	A0A388L9H5	A0A388LR25	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.	HIT domain-containing protein.	0.728
CBR_g28654	CBR_g4586	A0A388L9H5	A0A388KI81	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.	Uncharacterized protein.	0.999
CBR_g3480	CBR_g24123	A0A388JQZ7	A0A388L5V1	Uncharacterized protein.	PAPS_reduct domain-containing protein.	0.516
CBR_g3480	CBR_g39157	A0A388JQZ7	A0A388LR25	Uncharacterized protein.	HIT domain-containing protein.	0.704
CBR_g36815	CBR_g24123	A0A388LLR8	A0A388L5V1	Uncharacterized protein.	PAPS_reduct domain-containing protein.	0.944
CBR_g36815	CBR_g28654	A0A388LLR8	A0A388L9H5	Uncharacterized protein.	Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.	0.827

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.879

expected number of edges:

42

PPI enrichment p-value:

0.995

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

5 of 22

1.87

2.29

9.82e-06

GO:0009408

Response to heat

3 of 10

1.99

1.23

0.0041

GO:0051603

Proteolysis involved in protein catabolic process

2 of 4

2.21

0.79

0.0344

GO:0050821

Protein stabilization

2 of 4

2.21

0.79

0.0344

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 48

1.61

2.14

2.81e-06

GO:0051082

Unfolded protein binding

3 of 10

1.99

1.36

0.0022

GO:0140662

ATP-dependent protein folding chaperone

2 of 4

2.21

0.88

0.0237

GO:0004176

ATP-dependent peptidase activity

2 of 4

2.21

0.88

0.0237

GO:0140657

ATP-dependent activity

5 of 137

1.08

0.74

0.0085

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1235

0.46

0.38

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36350115

(2022) Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria.

2 of 3

2.34

1.12

0.0086

PMID:32093084

(2020) Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus.

3 of 26

1.58

0.98

0.0086

PMID:33780465

(2021) Adaptation of Dinoroseobacter shibae to oxidative stress and the specific role of RirA.

3 of 51

1.28

0.75

0.0186

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:378

Chaperone, and Cellular response to heat

10 of 16

2.31

7.89

5.09e-19

CL:381

Stress response, and Protein folding chaperone

8 of 10

2.42

6.85

2.99e-15

CL:384

Protein folding chaperone, and Chaperone binding

4 of 5

2.42

3.15

8.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236975

Antigen processing-Cross presentation

3 of 4

2.39

2.58

1.19e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

3 of 6

2.21

2.47

1.42e-05

MAP-1280218

Adaptive Immune System

3 of 6

2.21

2.47

1.42e-05

MAP-168256

Immune System

3 of 27

1.56

1.48

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009368

Endopeptidase Clp complex

2 of 3

2.34

0.86

0.0262

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

8 of 16

2.21

5.89

3.95e-14

KW-0143

Chaperone

5 of 23

1.85

2.62

9.96e-07

KW-0720

Serine protease

2 of 5

2.12

1.09

0.0088

KW-0645

Protease

3 of 34

1.46

0.93

0.0088

KW-0963

Cytoplasm

7 of 252

0.96

0.89

0.00018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00011

Hsp20/alpha crystallin family

3 of 3

2.51

1.95

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008978

HSP20-like chaperone

3 of 3

2.51

1.73

0.00064

IPR002068

Alpha crystallin/Hsp20 domain

3 of 3

2.51

1.73

0.00064

IPR037913

Small heat shock protein IbpA/IbpB, ACD domain

2 of 2

2.51

0.88

0.0255

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