CBR_g48604 protein (Chara braunii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

CBR_g48604

Amb_all domain-containing protein. (364 aa)

Predicted Functional Partners:

CBR_g16074

0.673

CBR_g8901

0.654

CBR_g21767

0.654

CBR_g9040

0.620

CBR_g8476

0.575

CBR_g35043

0.575

CBR_g35044

0.575

CBR_g72993

0.575

CBR_g22273

0.543

CBR_g55484

0.543

Your Current Organism:

Chara braunii

NCBI taxonomy Id: 69332
Other names: C. braunii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBR_g16074	CBR_g21767	A0A388JT65	A0A388L1D0	RING-type domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.986
CBR_g16074	CBR_g35043	A0A388JT65	A0A388LK30	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.964
CBR_g16074	CBR_g35044	A0A388JT65	A0A388LK52	RING-type domain-containing protein.	Uncharacterized protein; Belongs to the cullin family.	0.964
CBR_g16074	CBR_g48604	A0A388JT65	A0A388M353	RING-type domain-containing protein.	Amb_all domain-containing protein.	0.673
CBR_g16074	CBR_g72993	A0A388JT65	A0A388MGB3	RING-type domain-containing protein.	Cullin domain-containing protein; Belongs to the cullin family.	0.964
CBR_g16074	CBR_g8476	A0A388JT65	A0A388KM88	RING-type domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.973
CBR_g16074	CBR_g8901	A0A388JT65	A0A388KN78	RING-type domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.985
CBR_g21767	CBR_g16074	A0A388L1D0	A0A388JT65	Uncharacterized protein; Belongs to the SKP1 family.	RING-type domain-containing protein.	0.986
CBR_g21767	CBR_g35043	A0A388L1D0	A0A388LK30	Uncharacterized protein; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.906
CBR_g21767	CBR_g35044	A0A388L1D0	A0A388LK52	Uncharacterized protein; Belongs to the SKP1 family.	Uncharacterized protein; Belongs to the cullin family.	0.906
CBR_g21767	CBR_g48604	A0A388L1D0	A0A388M353	Uncharacterized protein; Belongs to the SKP1 family.	Amb_all domain-containing protein.	0.654
CBR_g21767	CBR_g72993	A0A388L1D0	A0A388MGB3	Uncharacterized protein; Belongs to the SKP1 family.	Cullin domain-containing protein; Belongs to the cullin family.	0.906
CBR_g21767	CBR_g8476	A0A388L1D0	A0A388KM88	Uncharacterized protein; Belongs to the SKP1 family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.938
CBR_g22273	CBR_g48604	A0A388L2J0	A0A388M353	Pectinesterase.	Amb_all domain-containing protein.	0.543
CBR_g35043	CBR_g16074	A0A388LK30	A0A388JT65	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.964
CBR_g35043	CBR_g21767	A0A388LK30	A0A388L1D0	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.906
CBR_g35043	CBR_g48604	A0A388LK30	A0A388M353	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Amb_all domain-containing protein.	0.575
CBR_g35043	CBR_g8901	A0A388LK30	A0A388KN78	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.906
CBR_g35044	CBR_g16074	A0A388LK52	A0A388JT65	Uncharacterized protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.964
CBR_g35044	CBR_g21767	A0A388LK52	A0A388L1D0	Uncharacterized protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the SKP1 family.	0.906

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.901

expected number of edges:

28

PPI enrichment p-value:

0.000165

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031398

Positive regulation of protein ubiquitination

5 of 12

2.94

5.24

1.84e-10

GO:1905786

Positive regulation of anaphase-promoting complex-dependent catabolic process

4 of 4

3.32

4.94

1.04e-09

GO:1901987

Regulation of cell cycle phase transition

6 of 88

2.15

4.16

1.04e-09

GO:0031145

Anaphase-promoting complex-dependent catabolic process

4 of 16

2.72

4.07

2.25e-08

GO:0010564

Regulation of cell cycle process

7 of 160

1.96

3.98

2.61e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990757

Ubiquitin ligase activator activity

4 of 4

3.32

4.69

3.06e-09

GO:0010997

Anaphase-promoting complex binding

4 of 4

3.32

4.69

3.06e-09

GO:0044877

Protein-containing complex binding

5 of 201

1.72

2.16

7.50e-06

GO:0004672

Protein kinase activity

4 of 431

1.29

0.89

0.0064

GO:0140096

Catalytic activity, acting on a protein

5 of 1397

0.87

0.5

0.0336

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005680

Anaphase-promoting complex

4 of 16

2.72

3.72

1.11e-07

GO:0000776

Kinetochore

4 of 45

2.27

2.93

1.61e-06

GO:0005815

Microtubule organizing center

3 of 78

1.91

1.64

0.00046

GO:0072686

Mitotic spindle

2 of 21

2.3

1.4

0.0024

GO:0005816

Spindle pole body

2 of 41

2.01

1.14

0.0066

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2484

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

8 of 28

2.78

8.78

6.03e-18

CL:2486

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

7 of 22

2.82

8.01

3.58e-16

CL:2488

Anaphase-promoting complex, and Mitotic checkpoint complex

4 of 17

2.69

3.86

5.69e-08

CL:2512

Mitotic checkpoint complex, and Mad3/Bub1 homology region 1

3 of 5

3.1

3.23

1.34e-06

CL:14564

Cohesin complex, and Meiotic spindle

2 of 10

2.62

1.34

0.0036

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

7 of 135

2.04

4.66

6.95e-12

map04111

Cell cycle - yeast

9 of 267

1.85

4.62

3.56e-14

map04120

Ubiquitin mediated proteolysis

4 of 198

1.63

1.72

8.87e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

5 of 18

2.76

5.07

2.68e-10

MAP-453276

Regulation of mitotic cell cycle

5 of 27

2.59

4.71

8.02e-10

MAP-174143

APC/C-mediated degradation of cell cycle proteins

5 of 27

2.59

4.71

8.02e-10

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

3 of 6

3.02

3.27

1.06e-06

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

3 of 6

3.02

3.27

1.06e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033597

Mitotic checkpoint complex

4 of 4

3.32

4.79

2.00e-09

GOCC:0015630

Microtubule cytoskeleton

4 of 130

1.81

1.76

0.00018

GOCC:0005819

Spindle

2 of 41

2.01

0.71

0.0470

GOCC:0110165

Cellular anatomical entity

11 of 10647

0.33

0.25

0.0470

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 149

1.75

1.76

0.00014

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033010

The WD repeat Cdc20/Fizzy family

4 of 4

3.32

4.52

6.29e-09

IPR015661

Mitotic spindle checkpoint protein Bub1/Mad3

2 of 2

3.32

1.59

0.0014

IPR013212

Mad3/Bub1 homology region 1

2 of 2

3.32

1.59

0.0014

IPR001680

WD40 repeat

4 of 164

1.71

1.35

0.0014

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

4 of 202

1.62

1.3

0.0014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00777

Mad3/BUB1 hoMad3/BUB1 homology region 1

2 of 2

3.32

1.9

0.00038

SM00320

WD40 repeats

4 of 174

1.68

1.55

0.00038

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