STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (808 aa)    
Predicted Functional Partners:
ADV43030.1
DEAD/DEAH box helicase domain protein; COGs: COG0514 Superfamily II DNA helicase; InterPro IPR014021: IPR001650: IPR011545: IPR014001; KEGG: bvu:BVU_2638 ATP-dependent DNA helicase; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: Putative uncharacterized protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase.
  
 0.952
ADV43547.1
KEGG: bth:BT_4376 hypothetical protein; SPTR: Putative uncharacterized protein.
  
    0.830
secD
Protein translocase subunit secF;protein translocase subunit secD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
  
  
 0.793
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.790
ADV45042.1
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR011895: IPR017900: IPR002880: IPR019752: IPR 019456: IPR011766: IPR017896; KEGG: bth:BT_1747 pyruvate-flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidored [...]
  
   0.771
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.764
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.717
ADV42947.1
KEGG: bth:BT_2817 putative TonB-dependent receptor; SPTR: Putative uncharacterized protein.
       0.683
ADV44507.1
COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR014016: IPR014017: IPR000212; KEGG: bfs:BF2555 putative helicase; PFAM: UvrD/REP helicase; SPTR: Putative uncharacterized protein; PFAM: UvrD/REP helicase.
 
 
 0.679
ADV42948.1
Tetratricopeptide TPR_1 repeat-containing protein; COGs: COG1729 conserved hypothetical protein; InterPro IPR019734: IPR013026: IPR001440; KEGG: bfs:BF4215 TPR repeat-containing protein; PFAM: Tetratricopeptide TPR_1 repeat-containing protein; SPTR: Putative uncharacterized protein; PFAM: Tetratricopeptide repeat.
       0.677
Your Current Organism:
Bacteroides helcogenes
NCBI taxonomy Id: 693979
Other names: B. helcogenes P 36-108, Bacteroides helcogenes DSM 20613, Bacteroides helcogenes P 36-108, Bacteroides helcogenes str. P 36-108, Bacteroides helcogenes strain P 36-108
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