STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (215 aa)    
Predicted Functional Partners:
bioB
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase apoenzyme; Catalyzes two activities which are involved in the biotine biosynthesis: the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L- methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8- diaminopelargonic acid (DAPA); In the C-terminal section; belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
 
 
 0.998
ADV44115.1
Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR006638: IPR007197: IPR005244; KEGG: bvu:BVU_0348 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Putative uncharacterized protein; PFAM: Radical SAM superfamily.
  
 
 0.983
bioC
Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
 
  
 0.970
ADV44063.1
Protein of unknown function DUF452; COGs: COG2830 conserved hypothetical protein; InterPro IPR007398; KEGG: bfr:BF1601 putative biotin synthesis protein BioC; PFAM: protein of unknown function DUF452; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF452).
 
     0.961
ADV44064.1
8-amino-7-oxononanoate synthase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839: IPR004723; KEGG: bth:BT_1443 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: Putative uncharacterized protein; TIGRFAM: 8-amino-7-oxononanoate synthase; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase.
 
  
 0.955
ADV44060.1
COGs: COG1215 Glycosyltransferase probably involved in cell wall biogenesis; InterPro IPR001173; KEGG: bth:BT_1472 hypothetical protein; PFAM: glycosyl transferase family 2; SPTR: Putative uncharacterized protein; PFAM: Glycosyl transferase family 2.
       0.734
ADV44287.1
Serine palmitoyltransferase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839: IPR001917; KEGG: bvu:BVU_3166 8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; PRIAM: Glycine C-acetyltransferase; SPTR: Putative uncharacterized protein; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase.
 
  
 0.721
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
 
  
 0.684
tdk
COGs: COG1435 Thymidine kinase; InterPro IPR020634: IPR001267; KEGG: bfs:BF0583 thymidine kinase; PFAM: thymidine kinase; PRIAM: Thymidine kinase; SPTR: Thymidine kinase; PFAM: Thymidine kinase.
 
      0.626
ADV44066.1
KEGG: bfr:BF1604 hypothetical protein; SPTR: Putative uncharacterized protein; manually curated.
       0.621
Your Current Organism:
Bacteroides helcogenes
NCBI taxonomy Id: 693979
Other names: B. helcogenes P 36-108, Bacteroides helcogenes DSM 20613, Bacteroides helcogenes P 36-108, Bacteroides helcogenes str. P 36-108, Bacteroides helcogenes strain P 36-108
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