STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ADV44173.1Precorrin-2 C20-methyltransferase; Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. (235 aa)    
Predicted Functional Partners:
ADV44183.1
COGs: COG2875 Precorrin-4 methylase; InterPro IPR002750: IPR000878: IPR003043: IPR006362; KEGG: bfr:BF2520 precorrin-4 C11-methyltransferase; PFAM: cobalamin (vitamin B12) biosynthesis CbiG protein; Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; PRIAM: Precorrin-4 C(11)-methyltransferase; SPTR: Putative uncharacterized protein; TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Cobalamin biosynthesis central region; Cobalamin synthesis G C-terminus; Tetrapyrrole (Corrin/Porphyrin) Methylases; Cobalamin synthesis G N-terminal; TIGRFAM: precorrin-4 C11-methyltransferase.
 
 
 0.999
ADV44185.1
COGs: COG1010 Precorrin-3B methylase; InterPro IPR000878: IPR003722: IPR006363; KEGG: bfr:BF2518 precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Precorrin-8X methylmutase CbiC/CobH; SPTR: Putative uncharacterized protein; TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Precorrin-8X methylmutase; Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase.
 
  
 0.996
cbiD
Cobalamin (vitamin B12) biosynthesis CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.995
ADV44190.1
Anaerobic cobaltochelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388: IPR019758; KEGG: bfr:BF2511 anaerobic cobalt chelatase CbiK; PFAM: anaerobic cobalt chelatase; PRIAM: Sirohydrochlorin cobaltochelatase; SPTR: Anaerobic cobalt chelatase CbiK; PFAM: Cobalt chelatase (CbiK).
 
 
 0.984
ADV44194.1
Anaerobic cobalt chelatase; COGs: COG4822 Cobalamin biosynthesis protein CbiK Co2+ chelatase; InterPro IPR010388; KEGG: pru:PRU_1084 cobalt chelatase; PFAM: anaerobic cobalt chelatase; SPTR: Heme-binding protein FetB; PFAM: Cobalt chelatase (CbiK).
 
 
 0.982
ADV44184.1
precorrin-6Y C5,15-methyltransferase (decarboxylating); COGs: COG2242 Precorrin-6B methylase 2; InterPro IPR010916: IPR006365: IPR012818: IPR014008; KEGG: bfs:BF2548 putative bifunctional CbiE/CbiT cobalamin biosynthesis protein; PRIAM: Precorrin-6Y C(5,15)-methyltransferase (decarboxylating); SPTR: Putative uncharacterized protein; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxyla [...]
 
  
 0.979
cobQ
Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.946
ADV44202.1
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing); COGs: COG1797 Cobyrinic acid a c-diamide synthase; InterPro IPR011698: IPR017929: IPR004484; KEGG: bfr:BF2503 cobyrinic acid a,c-diamide synthase; PFAM: CobB/CobQ domain protein glutamine amidotransferase; SPTR: Putative uncharacterized protein; TIGRFAM: cobyrinic acid a,c-diamide synthase; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; CobB/CobQ-like glutamine amidotransferase domain; TIGRFAM: cobyrinic acid a,c-diamide synthase.
 
  
 0.858
cobD
Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.831
cobS
Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.797
Your Current Organism:
Bacteroides helcogenes
NCBI taxonomy Id: 693979
Other names: B. helcogenes P 36-108, Bacteroides helcogenes DSM 20613, Bacteroides helcogenes P 36-108, Bacteroides helcogenes str. P 36-108, Bacteroides helcogenes strain P 36-108
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