STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV45219.1Phospholipase D/Transphosphatidylase; COGs: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; InterPro IPR001736; KEGG: bfs:BF3522 putative phospholipid biosynthesis related protein; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase; SPTR: Putative uncharacterized protein; PFAM: Phospholipase D Active site motif. (426 aa)    
Predicted Functional Partners:
ADV43247.1
Cardiolipin synthetase 2; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
  
  
 
0.918
ADV44913.1
COGs: COG1267 Phosphatidylglycerophosphatase A and related protein; InterPro IPR007686; KEGG: bth:BT_1525 phosphatidylglycerophosphatase A; PFAM: phosphatidylglycerophosphatase A; SPTR: Phosphatidylglycerophosphatase A; PFAM: Phosphatidylglycerophosphatase A.
     
 0.912
ADV45217.1
RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR014284: IPR000838: IPR007627: IPR013249; KEGG: bfs:BF3520 putative RNA polymerase sigma factor; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2; SPTR: RNA polymerase sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; Belongs to the sigma-70 factor family. ECF subfamily.
  
    0.728
ADV45216.1
KEGG: bfs:BF3519 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.717
ADV45218.1
KEGG: bfs:BF3521 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.717
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.658
ADV45221.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.543
ADV44946.1
Hypothetical protein; COGs: COG0822 NifU homolog involved in Fe-S cluster formation; KEGG: bth:BT_0174 hypothetical protein; SPTR: NifU-related domain containing protein.
   
 
 0.519
ADV43163.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: bth:BT_3820 putative DNA polymerase III, delta subunit; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase III, delta' subunit.
  
    0.432
Your Current Organism:
Bacteroides helcogenes
NCBI taxonomy Id: 693979
Other names: B. helcogenes P 36-108, Bacteroides helcogenes DSM 20613, Bacteroides helcogenes P 36-108, Bacteroides helcogenes str. P 36-108, Bacteroides helcogenes strain P 36-108
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