node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADQ78218.1 | ADQ78299.1 | Palpr_0056 | Palpr_0137 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | 0.942 |
ADQ78218.1 | ADQ78300.1 | Palpr_0056 | Palpr_0138 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912: IPR019455: IPR004789: IPR010916; KEGG: pdi:BDI_2071 acetohydroxyacid synthase small subunit; PFAM: amino acid-binding ACT domain protein; Acetolactate synthase, small subunit-like; SPTR: Putative uncharacterized protein; TIGRFAM: acetolactate synthase, small subunit; PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. | 0.957 |
ADQ78218.1 | ADQ78302.1 | Palpr_0056 | Palpr_0140 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.638 |
ADQ78218.1 | ADQ78327.1 | Palpr_0056 | Palpr_0165 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COGs: COG0527 Aspartokinase; InterProIPR011147: IPR001048: IPR002912: IPR005106: IPR 001342: IPR001341: IPR018042: IPR019811; KEGG: pdi:BDI_0261 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; SPTR: Aspartokinase/homoserine dehydrogenase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase. | 0.677 |
ADQ78218.1 | ADQ78531.1 | Palpr_0056 | Palpr_0370 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR017896: IPR011895: IPR002880: IPR019752: IPR 019456: IPR011766: IPR017900: IPR011894; KEGG: bfs:BF3168 putative pyruvate-flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; TIGRFAM: pyruvate ferredoxin/ [...] | 0.880 |
ADQ78218.1 | ADQ78679.1 | Palpr_0056 | Palpr_0520 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880: IPR005476; KEGG: pdi:BDI_1391 2-ketoisovalerate ferredoxin reductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain-containing protein; SPTR: Putative uncharacterized protein; PFAM: domain; Transketolase, C-terminal domain. | 0.811 |
ADQ78218.1 | ADQ80066.1 | Palpr_0056 | Palpr_1927 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880: IPR005479; KEGG: pdi:BDI_2807 putative oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate synthase; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit. | 0.836 |
ADQ78218.1 | ilvD | Palpr_0056 | Palpr_0136 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581: IPR004404: IPR020558; KEGG: bfr:BF3763 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.609 |
ADQ78218.1 | leuA | Palpr_0056 | Palpr_0052 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.918 |
ADQ78218.1 | leuB | Palpr_0056 | Palpr_0058 | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.817 |
ADQ78299.1 | ADQ78218.1 | Palpr_0137 | Palpr_0056 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | (R)-citramalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034; KEGG: pdi:BDI_2061 2-isopropylmalate synthase LeuA; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; PRIAM: (R)-citramalate synthase; SPTR: 2-isopropylmalate synthase LeuA; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.942 |
ADQ78299.1 | ADQ78300.1 | Palpr_0137 | Palpr_0138 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912: IPR019455: IPR004789: IPR010916; KEGG: pdi:BDI_2071 acetohydroxyacid synthase small subunit; PFAM: amino acid-binding ACT domain protein; Acetolactate synthase, small subunit-like; SPTR: Putative uncharacterized protein; TIGRFAM: acetolactate synthase, small subunit; PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit. | 0.999 |
ADQ78299.1 | ADQ78302.1 | Palpr_0137 | Palpr_0140 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.994 |
ADQ78299.1 | ADQ78327.1 | Palpr_0137 | Palpr_0165 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | COGs: COG0527 Aspartokinase; InterProIPR011147: IPR001048: IPR002912: IPR005106: IPR 001342: IPR001341: IPR018042: IPR019811; KEGG: pdi:BDI_0261 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: homoserine dehydrogenase; aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; SPTR: Aspartokinase/homoserine dehydrogenase; TIGRFAM: aspartate kinase; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase. | 0.765 |
ADQ78299.1 | ADQ78531.1 | Palpr_0137 | Palpr_0370 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterProIPR017896: IPR011895: IPR002880: IPR019752: IPR 019456: IPR011766: IPR017900: IPR011894; KEGG: bfs:BF3168 putative pyruvate-flavodoxin oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; Pyruvate-flavodoxin oxidoreductase, EKR domain; thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Pyruvate:ferredoxin (Flavodoxin) oxidoreductase; TIGRFAM: pyruvate ferredoxin/ [...] | 0.951 |
ADQ78299.1 | ADQ78679.1 | Palpr_0137 | Palpr_0520 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880: IPR005476; KEGG: pdi:BDI_1391 2-ketoisovalerate ferredoxin reductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain-containing protein; SPTR: Putative uncharacterized protein; PFAM: domain; Transketolase, C-terminal domain. | 0.912 |
ADQ78299.1 | ADQ80066.1 | Palpr_0137 | Palpr_1927 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880: IPR005479; KEGG: pdi:BDI_2807 putative oxidoreductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate synthase; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit. | 0.940 |
ADQ78299.1 | ilvD | Palpr_0137 | Palpr_0136 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; InterPro IPR000581: IPR004404: IPR020558; KEGG: bfr:BF3763 dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.986 |
ADQ78299.1 | leuA | Palpr_0137 | Palpr_0052 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.937 |
ADQ78299.1 | leuB | Palpr_0137 | Palpr_0058 | Acetolactate synthase, large subunit; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001: IPR012000: IPR011766: IPR012846; KEGG: pdi:BDI_2072 acetolactate synthase large subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; thiamine pyrophosphate central domain-containing protein; SPTR: Acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosph [...] | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.988 |