node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADQ78584.1 | ADQ78585.1 | Palpr_0424 | Palpr_0425 | Purine or other phosphorylase family 1; COGs: COG2820 Uridine phosphorylase; InterPro IPR000845; KEGG: bth:BT_4554 purine nucleoside phosphorylase II; PFAM: purine or other phosphorylase family 1; SPTR: Putative uncharacterized protein; PFAM: Phosphorylase superfamily. | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.451 |
ADQ78585.1 | ADQ78584.1 | Palpr_0425 | Palpr_0424 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | Purine or other phosphorylase family 1; COGs: COG2820 Uridine phosphorylase; InterPro IPR000845; KEGG: bth:BT_4554 purine nucleoside phosphorylase II; PFAM: purine or other phosphorylase family 1; SPTR: Putative uncharacterized protein; PFAM: Phosphorylase superfamily. | 0.451 |
ADQ78585.1 | ADQ78586.1 | Palpr_0425 | Palpr_0426 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR007627: IPR013249: IPR014284; KEGG: pdi:BDI_0526 RNA polymerase ECF-type sigma factor; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; SPTR: RNA polymerase ECF-type sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | 0.524 |
ADQ78585.1 | ADQ78795.1 | Palpr_0425 | Palpr_0639 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | 0.435 |
ADQ78585.1 | ADQ79514.1 | Palpr_0425 | Palpr_1368 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.454 |
ADQ78585.1 | ADQ80063.1 | Palpr_0425 | Palpr_1924 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489: IPR006390; KEGG: fps:FP1425 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase. | 0.965 |
ADQ78585.1 | ADQ80497.1 | Palpr_0425 | Palpr_2364 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.423 |
ADQ78585.1 | ADQ80870.1 | Palpr_0425 | Palpr_2740 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: bth:BT_3216 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inediphosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.900 |
ADQ78585.1 | ADQ80962.1 | Palpr_0425 | Palpr_2833 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.965 |
ADQ78585.1 | folE | Palpr_0425 | Palpr_2385 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | COGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602: IPR001474: IPR018234; KEGG: pgn:PGN_0667 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. | 0.671 |
ADQ78585.1 | ribBA | Palpr_0425 | Palpr_0989 | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.419 |
ADQ78586.1 | ADQ78585.1 | Palpr_0426 | Palpr_0425 | RNA polymerase, sigma-24 subunit, ECF subfamily; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR007627: IPR013249: IPR014284; KEGG: pdi:BDI_0526 RNA polymerase ECF-type sigma factor; PFAM: Sigma-70 region 4 type 2; sigma-70 region 2 domain protein; SPTR: RNA polymerase ECF-type sigma factor; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.524 |
ADQ78795.1 | ADQ78585.1 | Palpr_0639 | Palpr_0425 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.435 |
ADQ78795.1 | ADQ79514.1 | Palpr_0639 | Palpr_1368 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.409 |
ADQ78795.1 | ADQ80063.1 | Palpr_0639 | Palpr_1924 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489: IPR006390; KEGG: fps:FP1425 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; PRIAM: Dihydropteroate synthase; SPTR: Dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase. | 0.997 |
ADQ78795.1 | ADQ80497.1 | Palpr_0639 | Palpr_2364 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.436 |
ADQ78795.1 | ADQ80870.1 | Palpr_0639 | Palpr_2740 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: bth:BT_3216 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inediphosphokinase; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.908 |
ADQ78795.1 | ADQ80962.1 | Palpr_0639 | Palpr_2833 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.623 |
ADQ78795.1 | folE | Palpr_0639 | Palpr_2385 | FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR018109: IPR013221: IPR001645; KEGG: bvu:BVU_2328 putative folylpolyglutamate synthase; PFAM: Mur ligase middle domain protein; SPTR: Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. | COGs: COG0302 GTP cyclohydrolase I; InterPro IPR020602: IPR001474: IPR018234; KEGG: pgn:PGN_0667 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I. | 0.623 |
ADQ79514.1 | ADQ78585.1 | Palpr_1368 | Palpr_0425 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | KEGG: cps:CPS_2675 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; SPTR:2-amino-4-hydroxy-6-hydroxymethyldihydropterid inepyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.454 |