STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (348 aa)    
Predicted Functional Partners:
lpxC
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily.
 
 0.998
ADQ80559.1
acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
0.987
ADQ81157.1
lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
 
 0.987
ADQ79418.1
Metallophosphoesterase; COGs: COG2908 conserved hypothetical protein; InterPro IPR004843; KEGG: bvu:BVU_0525 UDP-2,3-diacylglucosamine hydrolase; PFAM: metallophosphoesterase; SPTR: UDP-2,3-diacylglucosamine hydrolase.
  
  
 0.924
ADQ79827.1
KpsF/GutQ family protein; COGs: COG0794 sugar phosphate isomerase involved in capsule formation; InterPro IPR000644: IPR001347: IPR004800; KEGG: str:Sterm_1811 KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; PRIAM: Arabinose-5-phosphate isomerase; SPTR: Polysialic acid capsule expression protein kpsF; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain; SIS domain; TIGRFAM: KpsF/GutQ family protein; Belongs to the SIS family. GutQ/KpsF subfamily.
 
  
 0.867
lpxK
lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
 
   
 0.852
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase; COGs: COG2877 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase; InterPro IPR006269: IPR006218: IPR010023: IPR006549; KEGG: str:Sterm_0385 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; SPTR: 3-deoxy-8-phosphooctulonate synthase; TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: DAHP synthetase I family; TIGRFAM: 3-deoxy-8-phosphooctulonate synthase; 3-deoxy-D-manno-octulosonate 8-phosphate [...]
 
  
 0.840
ADQ80728.1
Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
   
 0.839
kdsB
3-deoxy-D-manno- octulosonatecytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
   
 0.837
ADQ78764.1
COGs: COG1560 Lauroyl/myristoyl acyltransferase; InterPro IPR004960; KEGG: bvu:BVU_1062 putative acetyltransferase; PFAM: lipid A biosynthesis acyltransferase; SPTR: Putative acetyltransferase; PFAM: Bacterial lipid A biosynthesis acyltransferase.
 
   
 0.834
Your Current Organism:
Paludibacter propionicigenes
NCBI taxonomy Id: 694427
Other names: P. propionicigenes WB4, Paludibacter propionicigenes CCUG 53888, Paludibacter propionicigenes DSM 17365, Paludibacter propionicigenes JCM 13257, Paludibacter propionicigenes WB4, Paludibacter propionicigenes str. WB4, Paludibacter propionicigenes strain WB4
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