STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
secGPreprotein translocase subunit Sec61beta; Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex. (53 aa)    
Predicted Functional Partners:
pdxT
Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
       0.806
AGB38199.1
Thioredoxin domain-containing protein; IMG reference gene:2506731140; PFAM: Thioredoxin; TIGRFAM: thioredoxin.
       0.778
hisE
IMG reference gene:2506731144; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase.
       0.745
AGB38202.1
Hypothetical protein; IMG reference gene:2506731143; PFAM: Uncharacterised ACR, COG1259.
       0.601
secY
Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
    
 
 0.491
tatC
Sec-independent protein secretion pathway component TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes.
      
 0.438
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
      
 0.436
AGB38317.1
IMG reference gene:2506731269; TIGRFAM: protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic.
    
 
 0.427
Your Current Organism:
Natronococcus occultus
NCBI taxonomy Id: 694430
Other names: N. occultus SP4, Natronococcus occultus DSM 3396, Natronococcus occultus SP4, Natronococcus occultus str. SP4, Natronococcus occultus strain SP4
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