STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B7PSM1_IXOSCWH2 domain-containing protein. (476 aa)    
Predicted Functional Partners:
B7Q0Z5_IXOSC
Membrane-associated protein Hem, putative.
    
 0.993
Q4PMA3_IXOSC
Uncharacterized protein.
    
 0.990
B7P7H6_IXOSC
SH3 domain-containing protein.
   
 0.978
B7Q261_IXOSC
Cyfip2 protein, putative.
    
 0.967
B7Q262_IXOSC
Cytoplasmic FMR1interacting protein, putative.
    
 0.967
B7P5Z5_IXOSC
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
    
 0.832
B7QC67_IXOSC
Insulin receptor tyrosine kinase substrate, putative.
    
 0.831
B7QIL2_IXOSC
Dreadlocks/dock, putative (Fragment).
    
 0.763
B7PCP7_IXOSC
Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
     
 0.726
B7QB42_IXOSC
Arp2/3 complex 21 kD subunit, putative (Fragment).
    
 0.717
Your Current Organism:
Ixodes scapularis
NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.