STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B7PUV4_IXOSCHistone H2A; Belongs to the histone H2A family. (75 aa)    
Predicted Functional Partners:
B7PU75_IXOSC
MPN domain-containing protein, putative.
    
 0.978
Q4PM69_IXOSC
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.875
B7PEW4_IXOSC
Histone H2A; Belongs to the histone H2A family.
  
 0.794
B7QEK5_IXOSC
Histone demethylase, putative.
    
 0.784
B7QAA2_IXOSC
Histone H2B, putative; Belongs to the histone H2B family.
  
 0.780
B7PQK8_IXOSC
Histone H2B, putative; Belongs to the histone H2B family.
  
 0.779
Q4PM63_IXOSC
Histone H2B; Belongs to the histone H2B family.
  
 0.775
B7Q3Y4_IXOSC
Histone H2B, putative (Fragment); Belongs to the histone H2B family.
   
 0.735
B7P7T4_IXOSC
Histone H3; Belongs to the histone H3 family.
   
 0.724
B7PAJ2_IXOSC
Histone H3; Belongs to the histone H3 family.
   
 0.724
Your Current Organism:
Ixodes scapularis
NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.