STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B7Q2L8_IXOSCCell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (565 aa)    
Predicted Functional Partners:
B7P560_IXOSC
Origin recognition complex subunit, putative.
   
0.999
B7PL28_IXOSC
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
0.999
B7PMS7_IXOSC
Origin recognition complex, second largest subunit ORC2, putative.
   
 0.999
B7PR91_IXOSC
Origin recognition complex subunit, putative.
   
 0.999
B7QL56_IXOSC
DNA helicase; Belongs to the MCM family.
   
 0.998
B7PTW9_IXOSC
DNA helicase; Belongs to the MCM family.
   
 0.997
B7Q7M7_IXOSC
DNA replication licensing factor MCM5, putative; Belongs to the MCM family.
   
 0.997
B7QHT6_IXOSC
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
 0.996
B7P9P3_IXOSC
DNA replication factor Cdt1, putative.
   
 0.995
B7PCG8_IXOSC
DNA replication factor Cdt1, putative.
   
 0.995
Your Current Organism:
Ixodes scapularis
NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.