STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
B7Q3L5_IXOSCE3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (820 aa)    
Predicted Functional Partners:
B7PCM0_IXOSC
UBR-type domain-containing protein.
      
 0.605
B7QN06_IXOSC
Cullin, putative (Fragment); Belongs to the cullin family.
   
    0.595
B7QDA6_IXOSC
ATE_C domain-containing protein.
   
  
 0.558
B7QLB5_IXOSC
Zinc finger protein, putative.
    
 
 0.521
B7PMJ7_IXOSC
Zinc finger, c2h2 type domaincontaining protein.
      
 0.479
B7Q0U7_IXOSC
Ubiquitin protein ligase, putative; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.465
B7PU66_IXOSC
Ninein, putative.
      
 0.441
B7PD34_IXOSC
Nt_Gln_amidase domain-containing protein.
      
 0.432
B7QGD9_IXOSC
N-terminal Asn amidase, putative (Fragment).
      
 0.422
Your Current Organism:
Ixodes scapularis
NCBI taxonomy Id: 6945
Other names: I. scapularis, Ixodes dammini, Ixodes sp. DNAS-303-249710, black-legged tick, blacklegged tick, deer tick, shoulder tick
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