VP1G_04358 protein (Valsa mali) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

VP1G_04358

Serine/threonine-protein kinase HAL4/SAT4. (745 aa)

Predicted Functional Partners:

VP1G_04965

0.891

VP1G_04888

0.871

VP1G_06279

0.871

VP1G_01292

0.860

VP1G_04253

0.850

VP1G_00157

0.778

VP1G_07530

0.764

MCM7

0.763

VP1G_05530

0.755

VP1G_08615

0.745

Your Current Organism:

Valsa mali

NCBI taxonomy Id: 694573
Other names: V. mali var. pyri, Valsa mali var. pyri, Valsa sp. DD-2016

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	VP1G_00157	A0A194V0U6	A0A194ULU4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Topoisomerase 1-associated factor 1.	0.970
MCM7	VP1G_01292	A0A194V0U6	A0A194UPT2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Uncharacterized protein.	0.999
MCM7	VP1G_04358	A0A194V0U6	A0A194UZ95	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Serine/threonine-protein kinase HAL4/SAT4.	0.763
MCM7	VP1G_04888	A0A194V0U6	A0A194V0W8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	VP1G_04965	A0A194V0U6	A0A194V130	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Protein kinase rad3.	0.645
MCM7	VP1G_05530	A0A194V0U6	A0A194V2T6	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Exodeoxyribonuclease 1.	0.702
MCM7	VP1G_07530	A0A194V0U6	A0A194V8J2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA replication licensing factor mcm3; Belongs to the MCM family.	0.999
MCM7	VP1G_08615	A0A194V0U6	A0A194VBS0	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Cell cycle serine/threonine-protein kinase hsk1.	0.994
VP1G_00157	MCM7	A0A194ULU4	A0A194V0U6	Topoisomerase 1-associated factor 1.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.970
VP1G_00157	VP1G_01292	A0A194ULU4	A0A194UPT2	Topoisomerase 1-associated factor 1.	Uncharacterized protein.	0.988
VP1G_00157	VP1G_04253	A0A194ULU4	A0A194UZ61	Topoisomerase 1-associated factor 1.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.673
VP1G_00157	VP1G_04358	A0A194ULU4	A0A194UZ95	Topoisomerase 1-associated factor 1.	Serine/threonine-protein kinase HAL4/SAT4.	0.778
VP1G_00157	VP1G_04888	A0A194ULU4	A0A194V0W8	Topoisomerase 1-associated factor 1.	DNA helicase; Belongs to the MCM family.	0.985
VP1G_00157	VP1G_04965	A0A194ULU4	A0A194V130	Topoisomerase 1-associated factor 1.	Protein kinase rad3.	0.895
VP1G_00157	VP1G_05530	A0A194ULU4	A0A194V2T6	Topoisomerase 1-associated factor 1.	Exodeoxyribonuclease 1.	0.846
VP1G_00157	VP1G_06279	A0A194ULU4	A0A194V5C5	Topoisomerase 1-associated factor 1.	Mitosis inhibitor protein kinase wee1.	0.528
VP1G_00157	VP1G_07530	A0A194ULU4	A0A194V8J2	Topoisomerase 1-associated factor 1.	DNA replication licensing factor mcm3; Belongs to the MCM family.	0.974
VP1G_00157	VP1G_08615	A0A194ULU4	A0A194VBS0	Topoisomerase 1-associated factor 1.	Cell cycle serine/threonine-protein kinase hsk1.	0.944
VP1G_01292	MCM7	A0A194UPT2	A0A194V0U6	Uncharacterized protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
VP1G_01292	VP1G_00157	A0A194UPT2	A0A194ULU4	Uncharacterized protein.	Topoisomerase 1-associated factor 1.	0.988