Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
tolCOuter membrane protein. (401 aa)    
Predicted Functional Partners:
acrD
AcrB/AcrD/AcrF multidrug efflux protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 0.982
macB
ATP-binding protein of ABC transporter; Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.915
BARCL_0247
Homologs of previously reported genes of unknown function; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.903
BARCL_1290
Putative secretion protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.897
vceA
Multidrug resistance efflux pump VceA protein.
  
 
 0.772
BARCL_1263
Fragment of secretion protein (part 2).
  
 
 0.772
BARCL_0951
Homologs of previously reported genes of unknown function.
       0.605
BARCL_0949
Homologs of previously reported genes of unknown function.
       0.519
valS
Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
     
 0.511
bamA
Outer membrane protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
   
 0.505
Your Current Organism:
Bartonella clarridgeiae
NCBI taxonomy Id: 696125
Other names: B. clarridgeiae 73, Bartonella clarridgeiae 73, Bartonella clarridgeiae str. 73, Bartonella clarridgeiae strain 73
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