STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (432 aa)    
Predicted Functional Partners:
AEG58432.1
KEGG: drm:Dred_0071 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
 
 
 0.997
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.990
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.978
AEG58435.1
KEGG: drm:Dred_0072 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein.
  
  
 0.963
AEG58437.1
KEGG: drm:Dred_0074 thiazole biosynthesis protein ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein.
 
  
 0.956
AEG58438.1
KEGG: pth:PTH_0642 thiamine biosynthesis protein ThiF; TIGRFAM: thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein.
       0.814
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
  
 0.812
purM
TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: drm:Dred_2364 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein.
     
 0.811
AEG60484.1
PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: drm:Dred_2150 thiamine biosynthesis protein ThiH.
 
  
 0.745
AEG58434.1
KEGG: pth:PTH_0926 hypothetical protein; TIGRFAM: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase.
       0.720
Your Current Organism:
Desulfotomaculum ruminis
NCBI taxonomy Id: 696281
Other names: D. ruminis DSM 2154, Desulfotomaculum ruminis ATCC 23193, Desulfotomaculum ruminis DL, Desulfotomaculum ruminis DSM 2154, Desulfotomaculum ruminis str. DSM 2154, Desulfotomaculum ruminis strain DSM 2154
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