STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEG58437.1KEGG: drm:Dred_0074 thiazole biosynthesis protein ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein. (369 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 0.999
AEG58435.1
KEGG: drm:Dred_0072 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein.
 
    0.967
thiC
Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
 
  
 0.956
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.950
AEG59900.1
PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: drm:Dred_2150 thiamine biosynthesis protein ThiH.
  
  
 
0.917
AEG60484.1
PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: drm:Dred_2150 thiamine biosynthesis protein ThiH.
  
  
 
0.917
AEG58438.1
KEGG: pth:PTH_0642 thiamine biosynthesis protein ThiF; TIGRFAM: thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein.
 
    0.916
AEG58434.1
KEGG: pth:PTH_0926 hypothetical protein; TIGRFAM: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase.
       0.782
AEG58432.1
KEGG: drm:Dred_0071 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
 
  
 0.747
AEG59916.1
TIGRFAM: PAS sensor protein; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; response regulator receiver; Hpt domain protein; KEGG: drm:Dred_2145 multi-sensor hybrid histidine kinase; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS domain containing protein; response regulator receiver.
  
 
 0.732
Your Current Organism:
Desulfotomaculum ruminis
NCBI taxonomy Id: 696281
Other names: D. ruminis DSM 2154, Desulfotomaculum ruminis ATCC 23193, Desulfotomaculum ruminis DL, Desulfotomaculum ruminis DSM 2154, Desulfotomaculum ruminis str. DSM 2154, Desulfotomaculum ruminis strain DSM 2154
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