STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (450 aa)    
Predicted Functional Partners:
disA
DNA integrity scanning, DisA, linker region; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
  
  
 0.973
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.902
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins.
  
    0.813
AEG58560.1
KEGG: drm:Dred_0180 ATPase; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.
  
  
 0.775
AEG58558.1
PFAM: UvrB/UvrC protein; KEGG: drm:Dred_0178 UvrB/UvrC protein.
  
    0.753
AEG58565.1
KEGG: drm:Dred_0186 PilT domain-containing protein; PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc.
  
  
 0.726
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.715
AEG58557.1
PFAM: Firmicute transcriptional repressor of class III stress genes; KEGG: drm:Dred_0177 Firmicute transcriptional repressor of class III stress genes; Belongs to the CtsR family.
  
  
 0.676
AEG59572.1
KEGG: drm:Dred_2348 ATP-dependent DNA helicase PcrA; TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase.
  
  
 0.662
AEG59275.1
PFAM: UvrD/REP helicase; KEGG: mta:Moth_0254 UvrD/REP helicase.
  
  
 0.644
Your Current Organism:
Desulfotomaculum ruminis
NCBI taxonomy Id: 696281
Other names: D. ruminis DSM 2154, Desulfotomaculum ruminis ATCC 23193, Desulfotomaculum ruminis DL, Desulfotomaculum ruminis DSM 2154, Desulfotomaculum ruminis str. DSM 2154, Desulfotomaculum ruminis strain DSM 2154
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.