STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCProtein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (402 aa)    
Predicted Functional Partners:
AEG58522.1
PFAM: asparagine synthase; KEGG: drm:Dred_0151 PP-loop domain-containing protein.
 
 0.978
AEG59752.1
PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: cbe:Cbei_0561 NCAIR mutase (PurE)-related protein.
 
  
 0.978
AEG61575.1
PFAM: Protein of unknown function DUF2088; KEGG: dae:Dtox_0989 hypothetical protein.
 
  
 0.835
AEG59748.1
PFAM: aldo/keto reductase; KEGG: cbe:Cbei_0558 aldo/keto reductase.
 
    0.671
AEG58394.1
KEGG: dae:Dtox_0610 protein of unknown function DUF362.
 
     0.586
AEG59750.1
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.
       0.572
AEG59751.1
KEGG: amt:Amet_4635 hypothetical protein.
       0.572
AEG59271.1
KEGG: drm:Dred_2565 cobalt ABC transporter, inner membrane subunit CbiQ; TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein.
  
    0.558
AEG60660.1
KEGG: tpd:Teth39_1977 hypothetical protein.
 
  
 0.527
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
       0.454
Your Current Organism:
Desulfotomaculum ruminis
NCBI taxonomy Id: 696281
Other names: D. ruminis DSM 2154, Desulfotomaculum ruminis ATCC 23193, Desulfotomaculum ruminis DL, Desulfotomaculum ruminis DSM 2154, Desulfotomaculum ruminis str. DSM 2154, Desulfotomaculum ruminis strain DSM 2154
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