STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (246 aa)    
Predicted Functional Partners:
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
 
 
 0.999
AEG60469.1
PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: drm:Dred_1754 putative 6-pyruvoyl tetrahydropterin synthase.
 
 
 0.999
folE
TIGRFAM: GTP cyclohydrolase I; KEGG: drm:Dred_1758 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase.
  
  
 0.958
AEG60467.1
PFAM: protein of unknown function DUF366; KEGG: drm:Dred_1756 hypothetical protein.
 
     0.941
AEG61532.1
TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; KEGG: drm:Dred_0693 anaerobic ribonucleoside triphosphate reductase; PFAM: ATP-cone domain protein.
  
 
 0.800
AEG60464.1
KEGG: pth:PTH_1398 hypothetical protein.
 
     0.774
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
       0.766
AEG59204.1
PFAM: 2-hydroxyglutaryl-CoA dehydratase D-component; KEGG: drm:Dred_2688 2-hydroxyglutaryl-CoA dehydratase, D-component.
 
    0.750
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.645
queA
S-adenosylmethionine/tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
  
   
 0.626
Your Current Organism:
Desulfotomaculum ruminis
NCBI taxonomy Id: 696281
Other names: D. ruminis DSM 2154, Desulfotomaculum ruminis ATCC 23193, Desulfotomaculum ruminis DL, Desulfotomaculum ruminis DSM 2154, Desulfotomaculum ruminis str. DSM 2154, Desulfotomaculum ruminis strain DSM 2154
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