OJI94638.1 protein (Planktotalea frisia) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

OJI94638.1

EamA-like transporter family protein. (301 aa)

Predicted Functional Partners:

ribN_1

0.677

OJI94639.1

0.675

OJI92290.1

0.646

OJI92203.1

0.556

ribN_2

0.502

ribN_4

0.471

Your Current Organism:

Planktotalea frisia

NCBI taxonomy Id: 696762
Other names: DSM 23709, LMG 25294, LMG:25294, P. frisia, Planktotalea frisia Hahnke et al. 2012, Rhodobacteraceae bacterium SH6-1, strain SH6-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OJI92203.1	OJI94638.1	PFRI_35780	PFRI_11870	EamA-like transporter family protein.	EamA-like transporter family protein.	0.556
OJI92290.1	OJI94638.1	PFRI_34950	PFRI_11870	EamA-like transporter family protein.	EamA-like transporter family protein.	0.646
OJI94638.1	OJI92203.1	PFRI_11870	PFRI_35780	EamA-like transporter family protein.	EamA-like transporter family protein.	0.556
OJI94638.1	OJI92290.1	PFRI_11870	PFRI_34950	EamA-like transporter family protein.	EamA-like transporter family protein.	0.646
OJI94638.1	OJI94639.1	PFRI_11870	PFRI_11880	EamA-like transporter family protein.	Hypothetical protein.	0.675
OJI94638.1	ribN_1	PFRI_11870	PFRI_00460	EamA-like transporter family protein.	Riboflavin transporter.	0.677
OJI94638.1	ribN_2	PFRI_11870	PFRI_02090	EamA-like transporter family protein.	Riboflavin transporter.	0.502
OJI94638.1	ribN_4	PFRI_11870	PFRI_18650	EamA-like transporter family protein.	Riboflavin transporter.	0.471
OJI94639.1	OJI94638.1	PFRI_11880	PFRI_11870	Hypothetical protein.	EamA-like transporter family protein.	0.675
ribN_1	OJI94638.1	PFRI_00460	PFRI_11870	Riboflavin transporter.	EamA-like transporter family protein.	0.677
ribN_2	OJI94638.1	PFRI_02090	PFRI_11870	Riboflavin transporter.	EamA-like transporter family protein.	0.502
ribN_4	OJI94638.1	PFRI_18650	PFRI_11870	Riboflavin transporter.	EamA-like transporter family protein.	0.471

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.919

expected number of edges:

12

PPI enrichment p-value:

2.84e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017148

Negative regulation of translation

7 of 38

2.15

4.88

1.05e-11

GO:0000288

Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

6 of 27

2.23

4.51

2.67e-10

GO:0006401

RNA catabolic process

9 of 96

1.86

4.33

9.40e-13

GO:0006402

mRNA catabolic process

8 of 76

1.91

4.27

7.63e-12

GO:0000956

Nuclear-transcribed mRNA catabolic process

7 of 71

1.88

3.75

3.17e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004535

poly(A)-specific ribonuclease activity

3 of 4

2.76

2.23

8.28e-05

GO:0140098

Catalytic activity, acting on RNA

5 of 239

1.2

0.99

0.0016

GO:0003723

RNA binding

6 of 528

0.94

0.71

0.0035

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030015

CCR4-NOT core complex

6 of 6

2.88

6.45

6.98e-13

GO:0000932

P-body

6 of 29

2.2

4.39

4.04e-10

GO:0043232

Intracellular non-membrane-bounded organelle

7 of 988

0.73

0.52

0.0068

GO:0005634

Nucleus

9 of 2032

0.53

0.39

0.0078

GO:0032991

Protein-containing complex

8 of 1698

0.56

0.37

0.0188

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5685

CCR4-NOT core complex

5 of 5

2.88

5.31

1.20e-10

CL:5630

Mixed, incl. CCR4-NOT core complex, and RNA recognition motif

7 of 34

2.2

4.9

1.79e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

10 of 84

1.96

5.78

2.99e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6804115

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

5 of 7

2.74

4.93

4.71e-10

MAP-6791312

TP53 Regulates Transcription of Cell Cycle Genes

5 of 7

2.74

4.93

4.71e-10

MAP-429914

Deadenylation-dependent mRNA decay

7 of 41

2.12

4.62

3.65e-11

MAP-3700989

Transcriptional Regulation by TP53

5 of 149

1.41

1.46

0.00012

MAP-212436

Generic Transcription Pathway

6 of 230

1.3

1.44

3.40e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030014

CCR4-NOT complex

7 of 8

2.83

7.54

3.45e-15

GOCC:0030015

CCR4-NOT core complex

2 of 2

2.88

1.3

0.0045

GOCC:0032991

Protein-containing complex

9 of 2023

0.53

0.34

0.0298

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