STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEE95453.1Iron-only hydrogenase maturation protein HydG; COGs: COG1060 Thiamine biosynthesis protein ThiH; InterPro IPR007197: IPR010722: IPR018506; KEGG: slp:Slip_0120 biotin and thiamin synthesis associated; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SPTR: Biotin and thiamin synthesis associated; PFAM: Radical SAM superfamily; Biotin and Thiamin Synthesis associated domain; TIGRFAM: thiazole biosynthesis protein ThiH. (476 aa)    
Predicted Functional Partners:
AEE97367.1
Iron-only hydrogenase maturation protein HydF; COGs: COG1160 GTPase; InterPro IPR002917: IPR005225; KEGG: tex:Teth514_0683 small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; SPTR: Small GTP-binding protein; TIGRFAM: small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
  
 0.972
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
 0.969
AEE95452.1
KEGG: ate:Athe_0168 putative transcriptional regulator, CopG family; SPTR: Putative transcriptional regulator, CopG family.
 
     0.898
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.848
AEE96047.1
Flagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
   
    0.832
AEE96574.1
NAD(P)-dependent iron-only hydrogenase catalytic subunit; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR001041: IPR019574: IPR004108: IPR003149: IPR 017900: IPR000283: IPR017896: IPR013352; KEGG: mta:Moth_1717 iron hydrogenase, small subunit; PFAM: hydrogenase large subunit domain protein; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; iron hydrogenase small subunit; SPTR: Iron hydrogenase, small subunit; TIGRFAM: hydrogenase, Fe-only; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Iron only hydrogenase large subunit, C [...]
 
   
 0.815
AEE96448.1
NAD(P)-dependent iron-only hydrogenase catalytic subunit; COGs: COG4624 Iron only hydrogenase large subunit C-terminal domain; InterPro IPR001041: IPR019574: IPR004108: IPR003149: IPR 017900: IPR017896: IPR013352; KEGG: cth:Cthe_0342 hydrogenase, Fe-only; PFAM: hydrogenase large subunit domain protein; NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding; ferredoxin; iron hydrogenase small subunit; SPTR: Hydrogenase, Fe-only; TIGRFAM: hydrogenase, Fe-only; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Iron only hydrogenase large subunit, C-terminal domain; NADH-ubiquinone [...]
 
   
 0.809
AEE97220.1
KEGG: ant:Arnit_3051 hypothetical protein; SPTR: Putative uncharacterized protein.
  
  
 0.744
AEE95649.1
Radical SAM domain protein; COGs: COG0502 Biotin synthase; InterPro IPR005244: IPR007197: IPR006638; KEGG: csc:Csac_0491 biotin synthase; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: Biotin synthase; PFAM: Radical SAM superfamily.
 
  
0.724
spoIIAB
Anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
   
    0.674
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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