| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE95478.1 | AEE95479.1 | Mahau_0261 | Mahau_0262 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | 0.617 |
| AEE95478.1 | hisA | Mahau_0261 | Mahau_0268 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006063: IPR006062; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide [...] | 0.517 |
| AEE95478.1 | hisB | Mahau_0261 | Mahau_0266 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR020565; KEGG: tte:TTE2136 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.877 |
| AEE95478.1 | hisD | Mahau_0261 | Mahau_0265 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.956 |
| AEE95478.1 | hisF | Mahau_0261 | Mahau_0269 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.573 |
| AEE95478.1 | hisG | Mahau_0261 | Mahau_0264 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.546 |
| AEE95478.1 | hisH | Mahau_0261 | Mahau_0267 | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.734 |
| AEE95479.1 | AEE95478.1 | Mahau_0262 | Mahau_0261 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141: IPR010140: IPR004013; KEGG: cth:Cthe_0724 HisJ family histidinol phosphate phosphatase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Histidinol phosphate phosphatase HisJ family; TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain; TIGRFAM: histidinol phosphate phosphatase HisJ family; Belongs to the PHP hydrolase family. HisK subfamily. | 0.617 |
| AEE95479.1 | AEE95488.1 | Mahau_0262 | Mahau_0271 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063: IPR012089; KEGG: ate:Athe_2599 PP-loop domain protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop family; Belongs to the TtcA family. | 0.513 |
| AEE95479.1 | coaE | Mahau_0262 | Mahau_1180 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.725 |
| AEE95479.1 | hisA | Mahau_0262 | Mahau_0268 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006063: IPR006062; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide [...] | 0.512 |
| AEE95479.1 | hisB | Mahau_0262 | Mahau_0266 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR020565; KEGG: tte:TTE2136 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.522 |
| AEE95479.1 | hisD | Mahau_0262 | Mahau_0265 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.545 |
| AEE95479.1 | hisF | Mahau_0262 | Mahau_0269 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.512 |
| AEE95479.1 | hisG | Mahau_0262 | Mahau_0264 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.512 |
| AEE95479.1 | hisH | Mahau_0262 | Mahau_0267 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.512 |
| AEE95479.1 | hisZ | Mahau_0262 | Mahau_0263 | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.522 |
| AEE95488.1 | AEE95479.1 | Mahau_0271 | Mahau_0262 | PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063: IPR012089; KEGG: ate:Athe_2599 PP-loop domain protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop family; Belongs to the TtcA family. | COGs: COG1362 Aspartyl aminopeptidase; InterPro IPR001948; KEGG: tpd:Teth39_0781 putative aminopeptidase 1; PFAM: peptidase M18 aminopeptidase I; SPTR: M18 family aminopeptidase; PFAM: Aminopeptidase I zinc metalloprotease (M18). | 0.513 |
| AEE95488.1 | hisA | Mahau_0271 | Mahau_0268 | PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063: IPR012089; KEGG: ate:Athe_2599 PP-loop domain protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop family; Belongs to the TtcA family. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; InterPro IPR006063: IPR006062; KEGG: cth:Cthe_2887 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide [...] | 0.773 |
| AEE95488.1 | hisB | Mahau_0271 | Mahau_0266 | PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR011063: IPR012089; KEGG: ate:Athe_2599 PP-loop domain protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop family; Belongs to the TtcA family. | COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807: IPR020565; KEGG: tte:TTE2136 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. | 0.778 |
