STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
AEE95534.1Homocitrate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR002034: IPR013477: IPR000891; KEGG: tmt:Tmath_0527 homocitrate synthase; PFAM: pyruvate carboxyltransferase; SPTR: Homocitrate synthase; TIGRFAM: homocitrate synthase; PFAM: HMGL-like; TIGRFAM: homocitrate synthase NifV; Belongs to the alpha-IPM synthase/homocitrate synthase family. (386 aa)    
Predicted Functional Partners:
AEE97501.1
COGs: COG1454 Alcohol dehydrogenase class IV; InterPro IPR015590: IPR001670: IPR018211: IPR012079; KEGG: hmo:HM1_2632 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; SPTR: Aldehyde-alcohol dehydrogenase; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.921
AEE97905.1
2-isopropylmalate synthase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891: IPR013709: IPR002034: IPR005675; KEGG: cth:Cthe_2519 putative alpha-isopropylmalate/homocitrate synthase family transferase; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain-containing protein; SPTR: 2-isopropylmalate synthase; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM [...]
  
  
 
0.920
AEE95845.1
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880; KEGG: tte:TTE0961 pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxo [...]
  
 
 0.916
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 
0.911
AEE97019.1
Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880: IPR005476; KEGG: hor:Hore_06780 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin), alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain-containing protein; SPTR: Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; PFAM: domain; Transketolase, C-terminal domain.
   
 
 0.906
AEE97184.1
Pyruvate ferredoxin oxidoreductase, alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR002880; KEGG: csc:Csac_1460 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: Pyruvate ferredoxin oxidoreductase, alpha subunit; PFAM: domain.
   
 
 0.906
AEE95844.1
COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011896: IPR011766; KEGG: tte:TTE0960 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; PRIAM: 2-oxoglutarate synthase; SPTR: Pyruvate ferredoxin oxidoreductase beta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: 2-oxoacid:accep [...]
   
 
 0.905
AEE97018.1
Thiamine pyrophosphate TPP-binding domain-containing protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: hor:Hore_06790 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin), beta subunit; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: 3-methyl-2-oxobutanoate dehydrogenase (Ferredoxin), beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
   
 
 0.905
AEE97183.1
Thiamine pyrophosphate TPP-binding domain-containing protein; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: cth:Cthe_2393 thiamine pyrophosphate enzyme-like TPP-binding; PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; SPTR: Thiamine pyrophosphate enzyme-like TPP-binding; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
   
 
 0.905
AEE96881.1
COGs: COG0280 Phosphotransacetylase; InterPro IPR002505: IPR004614: IPR012147; KEGG: tte:TTE1482 phosphotransacetylase; PFAM: phosphate acetyl/butaryl transferase; PRIAM: Phosphate acetyltransferase; SPTR: Phosphotransacetylase; TIGRFAM: phosphate acetyltransferase; PFAM: Phosphate acetyl/butaryl transferase; TIGRFAM: phosphate acetyltransferase.
     
 0.904
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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