STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)    
Predicted Functional Partners:
AEE96152.1
Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.934
tmk-2
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
  
 
0.927
tmk-3
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
  
 
0.927
AEE95470.1
CMP/dCMP deaminase zinc-binding protein; COGs: COG2131 Deoxycytidylate deaminase; InterPro IPR002125: IPR016192: IPR016473; KEGG: chy:CHY_2556 putative ComE operon protein 2; PFAM: CMP/dCMP deaminase zinc-binding; SPTR: Putative comE operon protein 2; PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region.
    
 0.914
thyX
Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.914
surE
5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
  0.904
AEE95586.1
PSP1 domain protein; COGs: COG1774 Uncharacterized homolog of PSP1; InterPro IPR007557; KEGG: aoe:Clos_0063 PSP1 domain-containing protein; PFAM: PSP1 domain protein; SPTR: PSP1 domain protein; PFAM: PSP1 C-terminal conserved region.
 
    0.894
recR
DNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
    
 0.878
AEE95585.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR004622; KEGG: aoe:Clos_0062 DNA polymerase III, delta prime subunit; SPTR: DNA polymerase III, delta prime subunit; TIGRFAM: DNA polymerase III, delta prime subunit; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: DNA polymerase III, delta' subunit; DNA polymerase III, subunit gamma and tau.
 
  
 0.872
AEE95579.1
LL-diaminopimelate aminotransferase apoenzyme; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004838: IPR004839; KEGG: csc:Csac_0772 aspartate aminotransferase; PFAM: aminotransferase class I and II; SPTR: Aminotransferase; PFAM: Aminotransferase class I and II.
 
  
 0.817
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.