STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE95654.1ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR018368: IPR001270: IPR004176: IPR003959: IPR 001943: IPR013093: IPR019489: IPR003593; KEGG: tte:TTE2327 ATPase with chaperone activity, ATP-binding subunit; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATPases with chaperone activity, ATP-binding subunit; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family [...] (815 aa)    
Predicted Functional Partners:
mcsB
ATP:guanido phosphotransferase; Catalyzes the specific phosphorylation of arginine residues in proteins.
 
 
 0.969
AEE95652.1
UvrB/UvrC protein; COGs: COG3880 Uncharacterized protein with conserved CXXC pairs; InterPro IPR001943; KEGG: tte:TTE2329 hypothetical protein; PFAM: UvrB/UvrC protein; SPTR: UvrB/UvrC protein; PFAM: UvrB/uvrC motif.
 
  
 0.960
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.960
AEE95651.1
Transcriptional repressor, CtsR; COGs: COG4463 Transcriptional repressor of class III stress genes; InterPro IPR008463; KEGG: cno:NT01CX_1084 transcription regulator CtsR; PFAM: Firmicute transcriptional repressor of class III stress genes; SPTR: Transcription regulator ctsR; PFAM: Firmicute transcriptional repressor of class III stress genes (CtsR); Belongs to the CtsR family.
  
  
 0.940
AEE97556.1
KEGG: tpd:Teth39_0044 StbA family protein; SPTR: StbA family protein; PFAM: StbA protein.
  
 
 0.917
clpP
ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.916
AEE97945.1
Peptidase S14 ClpP; COGs: COG0740 Protease subunit of ATP-dependent Clp protease; InterPro IPR001907; KEGG: cth:Cthe_1629 peptidase S14, ClpP; PFAM: peptidase S14 ClpP; SPTR: ATP-dependent Clp protease proteolytic subunit; PFAM: Clp protease; TIGRFAM: ATP-dependent Clp protease, proteolytic subunit ClpP.
  
 
 0.899
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.895
AEE96141.1
COGs: COG0740 Protease subunit of ATP-dependent Clp protease; InterPro IPR002142; KEGG: cth:Cthe_1097 ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: peptidase S49; SPTR: ATP-dependent Clp protease proteolytic subunit ClpP; PFAM: Clp protease.
  
 
 0.892
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.889
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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