STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE95847.1Hypothetical protein; COGs: COG0616 Periplasmic serine protease (ClpP class); KEGG: ddf:DEFDS_0218 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Serine dehydrogenase proteinase. (275 aa)    
Predicted Functional Partners:
AEE95848.1
Rhomboid family protein; COGs: COG0705 membrane protein; InterPro IPR002610; KEGG: tpd:Teth39_1878 rhomboid family protein; PFAM: Rhomboid family protein; SPTR: Rhomboid family protein; PFAM: Rhomboid family.
 
  
 0.794
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.526
AEE95849.1
Natural resistance-associated macrophage protein; COGs: COG1914 Mn2+ and Fe2+ transporter of the NRAMP family; InterPro IPR001046; KEGG: ate:Athe_0657 natural resistance-associated macrophage protein; PFAM: natural resistance-associated macrophage protein; SPTR: Natural resistance-associated macrophage protein; PFAM: Natural resistance-associated macrophage protein; TIGRFAM: NRAMP (natural resistance-associated macrophage protein) metal ion transporters.
       0.493
AEE95850.1
MgtE intracellular region; COGs: COG2239 Mg/Co/Ni transporter MgtE (contains CBS domain); InterPro IPR000644: IPR007903: IPR006668; KEGG: csc:Csac_1222 MgtE intracellular region; PFAM: MgtE intracellular region; PRC-barrel domain protein; CBS domain containing protein; SPTR: MgtE intracellular region; PFAM: MgtE intracellular N domain; CBS domain; PRC-barrel domain.
       0.493
AEE97523.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR004176: IPR003959: IPR001943: IPR013093: IPR 019489: IPR001270: IPR018368: IPR003593; KEGG: tjr:TherJR_0243 ATPase AAA-2 domain protein; PFAM: ATPase AAA-2 domain protein; AAA ATPase central domain protein; Clp domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATPase AAA-2 domain protein; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities ( [...]
  
  
 0.470
AEE96065.1
COGs: COG1776 Chemotaxis protein CheC inhibitor of MCP methylation; InterPro IPR001172: IPR012826: IPR007597: IPR001543; KEGG: tte:TTE1429 flagellar motor switch protein; PFAM: surface presentation of antigens (SPOA) protein; CheC domain protein; SPTR: Chemotaxis protein CheC, inhibitor of MCP methylation; TIGRFAM: flagellar motor switch protein FliN; PFAM: Surface presentation of antigens (SPOA); CheC-like family; TIGRFAM: flagellar motor switch protein FliN.
     
 0.434
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.433
AEE96542.1
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterPro IPR004013: IPR002008: IPR002054: IPR003583: IPR 003141; KEGG: tte:TTE2516 family X DNA polymerase IV; PFAM: PHP domain protein; SMART: DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; phosphoesterase PHP domain protein; SPTR: DNA polymerase IV (Family X); manually curated; PFAM: PHP domain.
       0.432
ispH
Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
       0.432
nnrE
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
       0.432
Your Current Organism:
Mahella australiensis
NCBI taxonomy Id: 697281
Other names: M. australiensis 50-1 BON, Mahella australiensis 50-1 BON, Mahella australiensis DSM 15567, Mahella australiensis str. 50-1 BON, Mahella australiensis strain 50-1 BON
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